Characterization of Genes for Beef Marbling Based on Applying Gene Coexpression Network

Joint Authors

Park, Hye-Sun
Cho, Yong-Min
Lim, Dajeong
Kim, Nam-Kuk
Chai, Han-Ha
Lee, Seung-Hwan
Kim, Heebal

Source

International Journal of Genomics

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-01-30

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Biology

Abstract EN

Marbling is an important trait in characterization beef quality and a major factor for determining the price of beef in the Korean beef market.

In particular, marbling is a complex trait and needs a system-level approach for identifying candidate genes related to the trait.

To find the candidate gene associated with marbling, we used a weighted gene coexpression network analysis from the expression value of bovine genes.

Hub genes were identified; they were topologically centered with large degree and BC values in the global network.

We performed gene expression analysis to detect candidate genes in M.

longissimus with divergent marbling phenotype (marbling scores 2 to 7) using qRT-PCR.

The results demonstrate that transmembrane protein 60 (TMEM60) and dihydropyrimidine dehydrogenase (DPYD) are associated with increasing marbling fat.

We suggest that the network-based approach in livestock may be an important method for analyzing the complex effects of candidate genes associated with complex traits like marbling or tenderness.

American Psychological Association (APA)

Lim, Dajeong& Kim, Nam-Kuk& Lee, Seung-Hwan& Park, Hye-Sun& Cho, Yong-Min& Chai, Han-Ha…[et al.]. 2014. Characterization of Genes for Beef Marbling Based on Applying Gene Coexpression Network. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-492273

Modern Language Association (MLA)

Lim, Dajeong…[et al.]. Characterization of Genes for Beef Marbling Based on Applying Gene Coexpression Network. International Journal of Genomics No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-492273

American Medical Association (AMA)

Lim, Dajeong& Kim, Nam-Kuk& Lee, Seung-Hwan& Park, Hye-Sun& Cho, Yong-Min& Chai, Han-Ha…[et al.]. Characterization of Genes for Beef Marbling Based on Applying Gene Coexpression Network. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-492273

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-492273