Uptake and Tolerance of Chemotherapy in Elderly Patients with Small Cell Lung Cancer and Impact on Survival
Joint Authors
Winget, Marcy
al-Fayea, Turki M.
Butts, Charles
Fisher, Stacey
Gao, He
Source
Journal of Cancer Epidemiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The treatment of elderly cancer patients is complicated by many factors.
We sought to assess the uptake and tolerance of chemotherapy among patients 75 years and older diagnosed with small cell lung cancer (SCLC) in years 2004–2008 in Alberta, Canada, and assess their survival.
All patients who met the above criteria and had an oncologist-consult were included.
Data were obtained from the Alberta Cancer Registry and chart review.
A total of 171 patients were included in the study, 117 (68%) of whom began chemotherapy.
Of those, 52% completed all cycles, 66% did not have any dose reductions, and 31% completed all cycles at the recommended dose.
The risk of death for patients who did not complete all cycles of chemotherapy was 2.72 (95% CI: 1.52–4.87) and for those who completed all cycles but with a reduced dose was 1.02 (95% CI: 0.57–1.82) relative to those who completed chemotherapy at full dose after adjusting for several demographic/clinical factors.
Our results suggest that a significant proportion of elderly patients are able to tolerate chemotherapy and receive a survival benefit from it while those who experience toxicity may receive a survival benefit from a reduction in chemotherapy dose as opposed to stopping treatment.
American Psychological Association (APA)
Fisher, Stacey& al-Fayea, Turki M.& Winget, Marcy& Gao, He& Butts, Charles. 2012. Uptake and Tolerance of Chemotherapy in Elderly Patients with Small Cell Lung Cancer and Impact on Survival. Journal of Cancer Epidemiology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-492300
Modern Language Association (MLA)
Fisher, Stacey…[et al.]. Uptake and Tolerance of Chemotherapy in Elderly Patients with Small Cell Lung Cancer and Impact on Survival. Journal of Cancer Epidemiology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-492300
American Medical Association (AMA)
Fisher, Stacey& al-Fayea, Turki M.& Winget, Marcy& Gao, He& Butts, Charles. Uptake and Tolerance of Chemotherapy in Elderly Patients with Small Cell Lung Cancer and Impact on Survival. Journal of Cancer Epidemiology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-492300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492300