Transformation of Physical DVHs to Radiobiologically Equivalent Ones in Hypofractionated Radiotherapy Analyzing Dosimetric and Clinical Parameters : A Practical Approach for Routine Clinical Practice in Radiation Oncology
Joint Authors
Kelekis, Nikolaos
Patatoukas, George
Chaldeopoulos, Demetrios
Thrapsanioti, Zoi
Kouloulias, Vassilis
Efstathopoulos, Efstathios P.
Matsopoulos, George
Platoni, Kalliopi
Karanasiou, Irene
Dilvoi, Maria
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to transform DVHs from physical to radiobiological ones as well as to evaluate their reliability by correlations of dosimetric and clinical parameters for 50 patients with prostate cancer and 50 patients with breast cancer, who were submitted to Hypofractionated Radiotherapy.
Methods and Materials.
To achieve this transformation, we used both the linear-quadratic model (LQ model) and the Niemierko model.
The outcome of radiobiological DVHs was correlated with acute toxicity score according to EORTC/RTOG criteria.
Results.
Concerning the prostate radiotherapy, there was a significant correlation between RTOG acute rectal toxicity and D50 (P<0.001) and V60 (P=0.001) dosimetric parameters, calculated for α/β=10 Gy.
Moreover, concerning the breast radiotherapy there was a significant correlation between RTOG skin toxicity and V≥60 dosimetric parameter, calculated for both α/β=2.3 Gy (P<0.001) and α/β=10 Gy (P<0.001).
The new tool seems reliable and user-friendly.
Conclusions.
Our proposed model seems user-friendly.
Its reliability in terms of agreement with the presented acute radiation induced toxicity was satisfactory.
However, more patients are needed to extract safe conclusions.
American Psychological Association (APA)
Thrapsanioti, Zoi& Karanasiou, Irene& Platoni, Kalliopi& Efstathopoulos, Efstathios P.& Matsopoulos, George& Dilvoi, Maria…[et al.]. 2013. Transformation of Physical DVHs to Radiobiologically Equivalent Ones in Hypofractionated Radiotherapy Analyzing Dosimetric and Clinical Parameters : A Practical Approach for Routine Clinical Practice in Radiation Oncology. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-492619
Modern Language Association (MLA)
Thrapsanioti, Zoi…[et al.]. Transformation of Physical DVHs to Radiobiologically Equivalent Ones in Hypofractionated Radiotherapy Analyzing Dosimetric and Clinical Parameters : A Practical Approach for Routine Clinical Practice in Radiation Oncology. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-492619
American Medical Association (AMA)
Thrapsanioti, Zoi& Karanasiou, Irene& Platoni, Kalliopi& Efstathopoulos, Efstathios P.& Matsopoulos, George& Dilvoi, Maria…[et al.]. Transformation of Physical DVHs to Radiobiologically Equivalent Ones in Hypofractionated Radiotherapy Analyzing Dosimetric and Clinical Parameters : A Practical Approach for Routine Clinical Practice in Radiation Oncology. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-492619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492619