Antidiabetic and Antioxidant Properties of Triticum aestivum in Streptozotocin-Induced Diabetic Rats
Joint Authors
Mohan, Yogesha
Jesuthankaraj, Grace Nirmala
Ramasamy Thangavelu, Narendhirakannan
Source
Advances in Pharmacological Sciences
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The antidiabetic and antioxidant potential of Triticum aestivum were evaluated by using in vivo methods in normal and streptozotocin-induced diabetic rats.
Diabetes was induced in the Wistar strain albino rats by injecting streptozotocin at a dose of 55 mg/kg body weight.
Ethanolic extracts of Triticum aestivum at doses of 100 mg/kg body weight were administered orally for 30 days.
Various parameters were studied and the treatment group with the extract showed a significant increase in the liver glycogen and a significant decrease in fasting blood glucose, glycosylated hemoglobin levels, and serum marker enzyme levels.
The total cholesterol and serum triglycerides levels, low density lipoprotein, and very low density lipoprotein were also significantly reduced and the high density lipoprotein level was significantly increased upon treatment with the Triticum aestivum ethanol extract.
A significant decrease in the levels of lipid peroxides, superoxide dismutase, and glutathione peroxidise and increase in the levels of vitamin E, catalase, and reduced glutathione were observed in Triticum aestivum treated diabetic rats.
Thus, from this study we conclude that ethanolic extract of Triticum aestivum exhibited significant antihyperglycemic, hypolipidemic, and antioxidant activities in streptozotocin-induced diabetic rats.
American Psychological Association (APA)
Mohan, Yogesha& Jesuthankaraj, Grace Nirmala& Ramasamy Thangavelu, Narendhirakannan. 2013. Antidiabetic and Antioxidant Properties of Triticum aestivum in Streptozotocin-Induced Diabetic Rats. Advances in Pharmacological Sciences،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-492871
Modern Language Association (MLA)
Mohan, Yogesha…[et al.]. Antidiabetic and Antioxidant Properties of Triticum aestivum in Streptozotocin-Induced Diabetic Rats. Advances in Pharmacological Sciences No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-492871
American Medical Association (AMA)
Mohan, Yogesha& Jesuthankaraj, Grace Nirmala& Ramasamy Thangavelu, Narendhirakannan. Antidiabetic and Antioxidant Properties of Triticum aestivum in Streptozotocin-Induced Diabetic Rats. Advances in Pharmacological Sciences. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-492871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492871