The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation
Joint Authors
Neuman, Manuela G.
Nanau, Radu M.
Pritchett, Joshua C.
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Background.
There are challenges in the clinical diagnosis of drug-induced injury and in obtaining information on the reactivation of human herpes viruses (HHV) during idiosyncratic adverse drug reactions.
Objectives.
(i) To develop a unified list of drugs incriminated in drug-induced hepatotoxicity and severe cutaneous reactions, in which drug hypersensitivity leads to HHV-6 reactivation and further complication of therapy and recovery and (ii) to supplement the already available data on reporting frequencies of liver- or skin-induced cases with knowledge of individual case reports, including HHV-6 reactivation and briefly introducing chromosomally integrated HHV-6.
Data Sources and Extraction.
Drugs identified as causes of (i) idiosyncratic reactions, (ii) drug-induced hypersensitivity, drug-induced hepatotoxicity, acute liver failure, and Stevens-Johnson syndrome, and (iii) human herpes virus reactivation in PubMed since 1997 have been collected and discussed.
Results.
Data presented in this paper show that HHV-6 reactivation is associated with more severe organ involvement and a prolonged course of disease.
Conclusion.
This analysis of HHV-6 reactivation associated with drug-induced severe cutaneous reactions and hepatotoxicity will aid in causality assessment and clinical diagnosis of possible life-threatening events and will provide a basis for further patient characterization and therapy.
American Psychological Association (APA)
Pritchett, Joshua C.& Nanau, Radu M.& Neuman, Manuela G.. 2012. The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-493404
Modern Language Association (MLA)
Pritchett, Joshua C.…[et al.]. The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation. International Journal of Hepatology No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-493404
American Medical Association (AMA)
Pritchett, Joshua C.& Nanau, Radu M.& Neuman, Manuela G.. The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-493404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493404