Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival : A Scandinavian Single-Center Experience
Joint Authors
Taskén, Kjetil
Brudvik, Kristoffer Watten
Seeberg, Lars Thomas
Labori, Knut Jørgen
Bjørnbeth, Bjørn Atle
Waage, Anne
Bains, Simer Jit
Aandahl, Einar Martin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
We examined overall and disease-free survivals in a cohort of patients subjected to resection of liver metastasis from colorectal cancer (CRLM) in a 10-year period when new treatment strategies were implemented.
Methods.
Data from 239 consecutive patients selected for liver resection of CRLM during the period from 2002 to 2011 at a single center were used to estimate overall and disease-free survival.
The results were assessed against new treatment strategies and established risk factors.
Results.
The 5-year cumulative overall and disease-free survivals were 46 and 24%.
The overall survival was the same after reresection, independently of the number of prior resections and irrespectively of the location of the recurrent disease.
The time intervals between each recurrence were similar (11 ± 1 months).
Patients with high tumor load given neoadjuvant chemotherapy had comparable survival to those with less extensive disease without neoadjuvant chemotherapy.
Positive resection margin or resectable extrahepatic disease did not affect overall survival.
Conclusion.
Our data support that one still, and perhaps to an even greater extent, should seek an aggressive therapeutic strategy to achieve resectable status for recurrent hepatic and extrahepatic metastases.
The data should be viewed in the context of recent advances in the understanding of cancer biology and the metastatic process.
American Psychological Association (APA)
Brudvik, Kristoffer Watten& Bains, Simer Jit& Seeberg, Lars Thomas& Labori, Knut Jørgen& Waage, Anne& Taskén, Kjetil…[et al.]. 2013. Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival : A Scandinavian Single-Center Experience. HPB Surgery،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-493814
Modern Language Association (MLA)
Brudvik, Kristoffer Watten…[et al.]. Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival : A Scandinavian Single-Center Experience. HPB Surgery No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-493814
American Medical Association (AMA)
Brudvik, Kristoffer Watten& Bains, Simer Jit& Seeberg, Lars Thomas& Labori, Knut Jørgen& Waage, Anne& Taskén, Kjetil…[et al.]. Aggressive Treatment of Patients with Metastatic Colorectal Cancer Increases Survival : A Scandinavian Single-Center Experience. HPB Surgery. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-493814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493814