Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit’s Nictitating Membrane Response
Joint Authors
Wang, Desheng
Gonzalez-Joekes, Jimena
Smith-Bell, Carrie A.
Schreurs, Bernard G.
Bell, Roger
Burhans, Lauren B.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A rabbit model of Alzheimer’s disease based on feeding a cholesterol diet for eight weeks shows sixteen hallmarks of the disease, including learning and memory changes.
Although we have shown 2% cholesterol and copper in water can retard learning, other studies show feeding dietary cholesterol before learning can improve acquisition whereas feeding cholesterol after learning can degrade long-term memory.
We explored this issue by manipulating cholesterol concentration and duration following classical trace conditioning of the rabbit’s nictitating membrane response and assessed conditioned responding after eight weeks on cholesterol.
First, rabbits given trace classical conditioning followed by 0.5%, 1%, or 2% cholesterol for eight weeks showed body weight and serum cholesterol levels that were a function of dietary cholesterol.
Although all concentrations of cholesterol showed some sign of retarding long-term memory, the level of memory retardation was correlated with serum cholesterol levels.
Second, rabbits given trace conditioning followed by different durations of a 2% cholesterol diet combined with different durations of a 0% control diet for 8 weeks showed duration and timing of a 2% cholesterol diet were important in affecting recall.
The data support the idea that dietary cholesterol may retard long-term memory.
American Psychological Association (APA)
Schreurs, Bernard G.& Wang, Desheng& Smith-Bell, Carrie A.& Burhans, Lauren B.& Bell, Roger& Gonzalez-Joekes, Jimena. 2012. Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit’s Nictitating Membrane Response. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-494320
Modern Language Association (MLA)
Schreurs, Bernard G.…[et al.]. Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit’s Nictitating Membrane Response. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-494320
American Medical Association (AMA)
Schreurs, Bernard G.& Wang, Desheng& Smith-Bell, Carrie A.& Burhans, Lauren B.& Bell, Roger& Gonzalez-Joekes, Jimena. Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit’s Nictitating Membrane Response. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-494320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494320