Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions
Joint Authors
Wang, Liyun
Park, Sung-Soo
Becker, Kevin G.
Maudsley, Stuart
WoodIII, William H.
Stranahan, Alexis M.
Martin, Bronwen
Zhang, Yongqing
Chadwick, Wayne
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment.
The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity.
Severe disturbances in energy metabolism, such as those that occur in obesity, are therefore likely to be associated with disruption of hypothalamic transcriptomic plasticity.
In this paper, we investigated the effects of two well-characterized antiaging interventions, caloric restriction and voluntary wheel running, in two distinct physiological paradigms, that is, diabetic (db/db) and nondiabetic wild-type (C57/Bl/6) animals to investigate the contextual sensitivity of hypothalamic transcriptomic responses.
We found that, both quantitatively and qualitatively, caloric restriction and physical exercise were associated with distinct transcriptional signatures that differed significantly between diabetic and non-diabetic mice.
This suggests that challenges to metabolic homeostasis regulate distinct hypothalamic gene sets in diabetic and non-diabetic animals.
A greater understanding of how genetic background contributes to hypothalamic response mechanisms could pave the way for the development of more nuanced therapeutics for the treatment of metabolic disorders that occur in diverse physiological backgrounds.
American Psychological Association (APA)
Stranahan, Alexis M.& Martin, Bronwen& Chadwick, Wayne& Park, Sung-Soo& Wang, Liyun& Becker, Kevin G.…[et al.]. 2012. Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-494361
Modern Language Association (MLA)
Stranahan, Alexis M.…[et al.]. Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions. International Journal of Endocrinology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-494361
American Medical Association (AMA)
Stranahan, Alexis M.& Martin, Bronwen& Chadwick, Wayne& Park, Sung-Soo& Wang, Liyun& Becker, Kevin G.…[et al.]. Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-494361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494361