The Smoothing Artifact of Spatially Constrained Canonical Correlation Analysis in Functional MRI
Joint Authors
Nandy, Rajesh
Cordes, Dietmar
Curran, Tim
Jin, Mingwu
Source
International Journal of Biomedical Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A wide range of studies show the capacity of multivariate statistical methods for fMRI to improve mapping of brain activations in a noisy environment.
An advanced method uses local canonical correlation analysis (CCA) to encompass a group of neighboring voxels instead of looking at the single voxel time course.
The value of a suitable test statistic is used as a measure of activation.
It is customary to assign the value to the center voxel; however, this is a choice of convenience and without constraints introduces artifacts, especially in regions of strong localized activation.
To compensate for these deficiencies, different spatial constraints in CCA have been introduced to enforce dominance of the center voxel.
However, even if the dominance condition for the center voxel is satisfied, constrained CCA can still lead to a smoothing artifact, often called the “bleeding artifact of CCA”, in fMRI activation patterns.
In this paper a new method is introduced to measure and correct for the smoothing artifact for constrained CCA methods.
It is shown that constrained CCA methods corrected for the smoothing artifact lead to more plausible activation patterns in fMRI as shown using data from a motor task and a memory task.
American Psychological Association (APA)
Cordes, Dietmar& Jin, Mingwu& Curran, Tim& Nandy, Rajesh. 2012. The Smoothing Artifact of Spatially Constrained Canonical Correlation Analysis in Functional MRI. International Journal of Biomedical Imaging،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-494751
Modern Language Association (MLA)
Cordes, Dietmar…[et al.]. The Smoothing Artifact of Spatially Constrained Canonical Correlation Analysis in Functional MRI. International Journal of Biomedical Imaging No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-494751
American Medical Association (AMA)
Cordes, Dietmar& Jin, Mingwu& Curran, Tim& Nandy, Rajesh. The Smoothing Artifact of Spatially Constrained Canonical Correlation Analysis in Functional MRI. International Journal of Biomedical Imaging. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-494751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494751