A Large Cohort Study of Hypothyroidism and Hyperthyroidism in Relation to Gynecologic Cancers
Joint Authors
Tworoger, Shelley S.
Rosner, Bernard
Alexander, Erik
Kang, Jae H.
De Vivo, Immaculata
Curhan, Gary
Kueck, Angela S.
Stevens, Richard
Source
Obstetrics and Gynecology International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Thyroid status may influence tumorigenesis of gynecologic cancers, yet epidemiologic studies of this relationship are limited and inconsistent.
Methods.
We evaluated the association of self-reported history of physician-diagnosed hypothyroidism and hyperthyroidism with medical-record confirmed endometrial (EC; all invasive adenocarcinomas) and ovarian cancer (OC; epithelial ovarian or peritoneal cancers) in Nurses' Health Study (NHS) from 1976 to 2010 and NHSII from 1989 to 2011.
Cox proportional hazard models were used to estimate multivariable rate ratios (RRs) and 95% confidence intervals based on pooled cohort data.
Results.
We confirmed 1314 incident cases of EC and 1150 cases of OC.
Neither a history of hypothyroidism nor hyperthyroidism was significantly associated with risk of EC or OC.
However, having a history of hypothyroidism for 8+ years (median) was nonsignificantly inversely associated with EC (RR = 0.81; 95% CI = 0.63–1.04; P-trend with history duration = 0.11) and OC (RR = 0.87, 95% CI = 0.66–1.15; P-trend = 0.13).
Having a history of hyperthyroidism for 6+ years (median) was non-significantly positively associated with EC (RR = 1.69; 95% CI = 0.86–3.30; P-trend = 0.12) but not OC (RR = 1.12; 95% CI = 0.46–2.72; P-trend = 0.95).
Conclusions.
A history of hypothyroidism or hyperthyroidism was not significantly associated with risk of EC or OC.
American Psychological Association (APA)
Kang, Jae H.& Kueck, Angela S.& Stevens, Richard& Curhan, Gary& De Vivo, Immaculata& Rosner, Bernard…[et al.]. 2013. A Large Cohort Study of Hypothyroidism and Hyperthyroidism in Relation to Gynecologic Cancers. Obstetrics and Gynecology International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495246
Modern Language Association (MLA)
Kang, Jae H.…[et al.]. A Large Cohort Study of Hypothyroidism and Hyperthyroidism in Relation to Gynecologic Cancers. Obstetrics and Gynecology International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-495246
American Medical Association (AMA)
Kang, Jae H.& Kueck, Angela S.& Stevens, Richard& Curhan, Gary& De Vivo, Immaculata& Rosner, Bernard…[et al.]. A Large Cohort Study of Hypothyroidism and Hyperthyroidism in Relation to Gynecologic Cancers. Obstetrics and Gynecology International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495246