Renal Transplantation in Systemic Lupus Erythematosus : Outcome and Prognostic Factors in 50 Cases from a Single Centre
Joint Authors
Glucksmann, Constanza
Cervera, Ricard
Ercilla, Guadalupe
Oppenheimer, Federico
Sanchez-Marcos, Carolina
Cairoli, Ernesto
Espinosa, Gerard
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
End-stage renal disease (ESRD) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE).
Objectives.
To analyze the outcome and prognostic factors of renal transplantation in patients with ESRD due to SLE from January 1986 to December 2013 in a single center.
Results.
Fifty renal transplantations were performed in 40 SLE patients (32 female (80%), mean age at transplantation 36 ± 10.4 years).
The most frequent lupus nephropathy was type IV (72.2%).
Graft failure occurred in a total of 15 (30%) transplantations and the causes of graft failure were chronic allograft nephropathy (n=12), acute rejection (n=2), and chronic humoral rejection (1).
The death-censored graft survival rates were 93.9% at 1 year, 81.5% at 5 years, and 67.6% at the end of study.
The presence of deceased donor allograft (P=0.007) and positive anti-HCV antibodies (P=0.001) negatively influence the survival of the renal transplant.
The patient survival rate was 91.4% at the end of the study.
Recurrence of lupus nephritis in renal allograft was observed in one patient.
Conclusion.
Renal transplantation is a good alternative for renal replacement therapy in patients with SLE.
In our cohort, the presence of anti-HCV antibodies and the type of donor source were related to the development of graft failure.
American Psychological Association (APA)
Cairoli, Ernesto& Sanchez-Marcos, Carolina& Espinosa, Gerard& Glucksmann, Constanza& Ercilla, Guadalupe& Oppenheimer, Federico…[et al.]. 2014. Renal Transplantation in Systemic Lupus Erythematosus : Outcome and Prognostic Factors in 50 Cases from a Single Centre. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-495386
Modern Language Association (MLA)
Cairoli, Ernesto…[et al.]. Renal Transplantation in Systemic Lupus Erythematosus : Outcome and Prognostic Factors in 50 Cases from a Single Centre. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-495386
American Medical Association (AMA)
Cairoli, Ernesto& Sanchez-Marcos, Carolina& Espinosa, Gerard& Glucksmann, Constanza& Ercilla, Guadalupe& Oppenheimer, Federico…[et al.]. Renal Transplantation in Systemic Lupus Erythematosus : Outcome and Prognostic Factors in 50 Cases from a Single Centre. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-495386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495386