Establishing Reliable miRNA-Cancer Association Network Based on Text-Mining Method
Joint Authors
Yang, Zhaowan
Zhang, Libin
Hu, Xingchi
Li, Lun
Fang, Ming
Jia, Zhenyu
Zhou, Yanhong
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Associating microRNAs (miRNAs) with cancers is an important step of understanding the mechanisms of cancer pathogenesis and finding novel biomarkers for cancer therapies.
In this study, we constructed a miRNA-cancer association network (miCancerna) based on more than 1,000 miRNA-cancer associations detected from millions of abstracts with the text-mining method, including 226 miRNA families and 20 common cancers.
We further prioritized cancer-related miRNAs at the network level with the random-walk algorithm, achieving a relatively higher performance than previous miRNA disease networks.
Finally, we examined the top 5 candidate miRNAs for each kind of cancer and found that 71% of them are confirmed experimentally.
miCancerna would be an alternative resource for the cancer-related miRNA identification.
American Psychological Association (APA)
Li, Lun& Hu, Xingchi& Yang, Zhaowan& Jia, Zhenyu& Fang, Ming& Zhang, Libin…[et al.]. 2014. Establishing Reliable miRNA-Cancer Association Network Based on Text-Mining Method. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-495468
Modern Language Association (MLA)
Li, Lun…[et al.]. Establishing Reliable miRNA-Cancer Association Network Based on Text-Mining Method. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-495468
American Medical Association (AMA)
Li, Lun& Hu, Xingchi& Yang, Zhaowan& Jia, Zhenyu& Fang, Ming& Zhang, Libin…[et al.]. Establishing Reliable miRNA-Cancer Association Network Based on Text-Mining Method. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-495468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495468