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Postangioplasty Restenosis Followed with Magnetic Resonance Imaging in an Atherosclerotic Rabbit Model
Joint Authors
Hänni, Mari
Smedby, Örjan
Leppänen, Olli
Source
International Journal of Biomedical Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Rationale and Objectives.
Testing a quantitative, noninvasive method to assess postangioplasty vessel wall changes in an animal model.
Material and Methods.
Six New Zealand white rabbits were subjected to atherosclerotic injury, including cholesterol-enriched diet, deendothelialization, and percutaneous transluminal angioplasty (PTA) in the distal part of abdominal aorta (four weeks after deendothelialization).
The animals were examined with a 1.5T MRI scanner at three times as follows: baseline (six weeks after diet start and two days after PTA) and four weeks and 10 weeks after-PTA.
Inflow angiosequence (M2DI) and proton-density-weighted sequence (PDW) were performed to examine the aorta with axial slices.
To identify the inner and outer vessel wall boundaries, a dynamic contour algorithm (Gradient Vector Flow Snakes) was applied to the images, followed by calculation of the vessel wall dimensions.
The results were compared with histopathological analysis.
Results.
The wall thickness in the lesion was significantly higher than in the control region at 4 and 10 weeks, reflecting induction of experimentally created after-angioplasty lesion.
At baseline, no significant difference between the two regions was present.
Conclusions.
It is possible to follow the development of vessel wall changes after-PTA with MRI in this rabbit model.
American Psychological Association (APA)
Hänni, Mari& Leppänen, Olli& Smedby, Örjan. 2012. Postangioplasty Restenosis Followed with Magnetic Resonance Imaging in an Atherosclerotic Rabbit Model. International Journal of Biomedical Imaging،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-495485
Modern Language Association (MLA)
Hänni, Mari…[et al.]. Postangioplasty Restenosis Followed with Magnetic Resonance Imaging in an Atherosclerotic Rabbit Model. International Journal of Biomedical Imaging No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-495485
American Medical Association (AMA)
Hänni, Mari& Leppänen, Olli& Smedby, Örjan. Postangioplasty Restenosis Followed with Magnetic Resonance Imaging in an Atherosclerotic Rabbit Model. International Journal of Biomedical Imaging. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-495485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495485