Further Increase in the Expression of Activation Markers on Monocyte-Derived Dendritic Cells in Coronary Artery Disease Patients with Ectasia Compared to Patients with Coronary Artery Disease Alone
Joint Authors
Aydin, Mustafa
Yildirim, Nesligul
Arasli, Muhammad
Tekin, Ishak Ozel
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Coronary artery ectasia (CAE) is defined as localized or diffuse dilation of the coronary arteries.
There are scarce data about the role of dendritic cells in CAE development.
In this study we investigated the activation markers on the surface of monocyte-derived dendritic cells (mDCs) in coronary artery disease (CAD) patients with or without CAE.
Method.
The study consisted of 6 patients who had obstructive CAD with CAE, 6 CAD patients without CAE and 6 subjects with angiographically normal coronary arteries.
mDCs were cultivated from peripheral blood monocytes.
Surface activation markers were detected by flow cytometry.
Results.
CAD patients with CAE were detected to have significantly higher mean fluorescence intensities of CD11b, CD11c, CD54 , CD83, CD86 and MHC Class II molecules on mDCs in comparison to CAD patients without CAE and normal controls (P<.001 for all).
A significant positive correlation was found between the number of vessels with CAE and the levels of CD11c, CD86, and MHC Class II molecules.
Conclusion.
mDCs display an increased cell surface concentration of activation molecules in CAD patients with CAE compared to patients with CAD alone.
DC activation may play an important role for CAE development in patients with CAD.
American Psychological Association (APA)
Yildirim, Nesligul& Tekin, Ishak Ozel& Arasli, Muhammad& Aydin, Mustafa. 2010. Further Increase in the Expression of Activation Markers on Monocyte-Derived Dendritic Cells in Coronary Artery Disease Patients with Ectasia Compared to Patients with Coronary Artery Disease Alone. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-495620
Modern Language Association (MLA)
Yildirim, Nesligul…[et al.]. Further Increase in the Expression of Activation Markers on Monocyte-Derived Dendritic Cells in Coronary Artery Disease Patients with Ectasia Compared to Patients with Coronary Artery Disease Alone. Mediators of Inflammation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-495620
American Medical Association (AMA)
Yildirim, Nesligul& Tekin, Ishak Ozel& Arasli, Muhammad& Aydin, Mustafa. Further Increase in the Expression of Activation Markers on Monocyte-Derived Dendritic Cells in Coronary Artery Disease Patients with Ectasia Compared to Patients with Coronary Artery Disease Alone. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-495620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495620