Extracellular Matrix Modulates Angiogenesis in Physiological and Pathological Conditions
Joint Authors
Maruotti, Nicola
Neve, Anna
Cantatore, Francesco Paolo
Ribatti, Domenico
Corrado, Addolorata
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Angiogenesis is a multistep process driven by a wide range of positive and negative regulatory factors.
Extracellular matrix (ECM) plays a crucial role in the regulation of this process.
The degradation of ECM, occurring in response to an angiogenic stimulus, leads to degradation or partial modification of matrix molecules, release of soluble factors, and exposure of cryptic sites with pro- and/or antiangiogenic activity.
ECM molecules and fragments, resulting from proteolysis, can also act directly as inflammatory stimuli, and this can explain the exacerbated angiogenesis that drives and maintains several inflammatory diseases.
In this review we have summarized some of the more recent literature data concerning the molecular control of ECM in angiogenesis in both physiological and pathological conditions.
American Psychological Association (APA)
Neve, Anna& Cantatore, Francesco Paolo& Maruotti, Nicola& Corrado, Addolorata& Ribatti, Domenico. 2014. Extracellular Matrix Modulates Angiogenesis in Physiological and Pathological Conditions. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-496214
Modern Language Association (MLA)
Neve, Anna…[et al.]. Extracellular Matrix Modulates Angiogenesis in Physiological and Pathological Conditions. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-496214
American Medical Association (AMA)
Neve, Anna& Cantatore, Francesco Paolo& Maruotti, Nicola& Corrado, Addolorata& Ribatti, Domenico. Extracellular Matrix Modulates Angiogenesis in Physiological and Pathological Conditions. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-496214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496214