The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran
Joint Authors
Aminian, Keyvan
Seighalani, Ramin
Tarang, Alireza
Faghani, Masoumeh
Mansour-Ghanaei, Fariborz
Javadi, Azadeh
Fakhrieh Asl, Saba
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran.
Materials and Methods.
A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied.
No patients had positive family history of cancers.
The frequencies of MSI were analyzed by testing the BAT-26 and BAT-25 markers.
Results.
MSI analysis revealed that 22.9% of the tumors (22 patients) were microsatellite instability positive and 77.1% (74 patients) were microsatellite instability negative.
The highest rate of MSI (40.9%) was found in the rectal region.
MSI-H status was seen more frequently in distal tumors (P=0.04, odds ratio = 3.13, 0.96–10.14).
Conclusions.
Distal tumor location and MSI may associate with special clinicopathological features.
It seems that there may be correlation with underlying genetic and immunologic mechanisms.
American Psychological Association (APA)
Faghani, Masoumeh& Fakhrieh Asl, Saba& Mansour-Ghanaei, Fariborz& Aminian, Keyvan& Tarang, Alireza& Seighalani, Ramin…[et al.]. 2012. The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-496236
Modern Language Association (MLA)
Faghani, Masoumeh…[et al.]. The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran. Gastroenterology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-496236
American Medical Association (AMA)
Faghani, Masoumeh& Fakhrieh Asl, Saba& Mansour-Ghanaei, Fariborz& Aminian, Keyvan& Tarang, Alireza& Seighalani, Ramin…[et al.]. The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-496236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496236
