![](/images/graphics-bg.png)
Ductal Carcinoma In Situ of the Breast : A Surgical Perspective
Author
Source
International Journal of Surgical Oncology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous neoplasm with invasive potential.
Risk factors include age, family history, hormone replacement therapy, genetic mutation, and patient lifestyle.
The incidence of DCIS has increased due to more widespread use of screening and diagnostic mammography; almost 80% of cases are diagnosed with imaging with final diagnosis established by biopsy and histological examination.
There are various classification systems used for DCIS, the most recent of which is based on the presence of intraepithelial neoplasia of the ductal epithelium (DIN).
A number of molecular assays are now available that can identify high-risk patients as well as help establish the prognosis of patients with diagnosed DCIS.
Current surgical treatment options include total mastectomy, simple lumpectomy in very low-risk patients, and lumpectomy with radiation.
Adjuvant therapy is tailored based on the molecular profile of the neoplasm and can include aromatase inhibitors, anti-estrogen, anti-progesterone (or a combination of antiestrogen and antiprogesterone), and HER2 neu suppression therapy.
Chemopreventive therapies are under investigation for DCIS, as are various molecular-targeted drugs.
It is anticipated that new biologic agents, when combined with hormonal agents such as SERMs and aromatase inhibitors, may one day prevent all forms of breast cancer.
American Psychological Association (APA)
Badruddoja, Mohammed. 2012. Ductal Carcinoma In Situ of the Breast : A Surgical Perspective. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-496689
Modern Language Association (MLA)
Badruddoja, Mohammed. Ductal Carcinoma In Situ of the Breast : A Surgical Perspective. International Journal of Surgical Oncology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-496689
American Medical Association (AMA)
Badruddoja, Mohammed. Ductal Carcinoma In Situ of the Breast : A Surgical Perspective. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-496689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496689