Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GCMS Metabolomics
Joint Authors
Liu, Pu-Zhao
Song, Hai-Yan
Zhao, Yu-Ping
Dong, Yang
Li, Ming
Ding, Yue
Shi, Jian-Rong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To investigate the correlation between presbycusis and kidney deficiency as defined by traditional Chinese medicine (TCM) and its material basis from the perspective of metabolism.
Methods.
Pure-tone audiometry was used to test auditory function.
A kidney deficiency symptom scoring table was used to measure the kidney deficiency accumulated scores of the research subjects.
Gas chromatography/mass spectrometry (GC/MS) was used to measure the metabolites in the urine samples from 11 presbycusis patients and 9 elderly people with normal hearing.
Results.
Hearing loss in the elderly was positively correlated with kidney deficiency score in TCM.
There were significant differences in urine metabolite profile between the presbycusis patients and the controls.
A total of 23 differentially expressed metabolites were found.
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that these metabolites were related to glutathione metabolism, amino acid metabolism, glucose metabolism, the N-methyl-D-aspartic acid (NMDA) receptor pathway, and the γ-aminobutyric acid (GABA) receptor pathway.
Conclusion.
Glutathione metabolism, amino acid metabolism, glucose metabolism, NMDA receptors, and GABA receptors may be related to the pathogenesis of presbycusis and may be the material basis underlying the correlation between presbycusis and kidney deficiency in TCM.
American Psychological Association (APA)
Dong, Yang& Ding, Yue& Liu, Pu-Zhao& Song, Hai-Yan& Zhao, Yu-Ping& Li, Ming…[et al.]. 2013. Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GCMS Metabolomics. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-496766
Modern Language Association (MLA)
Dong, Yang…[et al.]. Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GCMS Metabolomics. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-496766
American Medical Association (AMA)
Dong, Yang& Ding, Yue& Liu, Pu-Zhao& Song, Hai-Yan& Zhao, Yu-Ping& Li, Ming…[et al.]. Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GCMS Metabolomics. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-496766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496766