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Effects of Spirulina on Cyclophosphamide-Induced Ovarian Toxicity in Rats : Biochemical and Histomorphometric Evaluation of the Ovary
Joint Authors
Aksungar, Fehime
Celik, Aygen
Ilter, Erdin
Midi, Ahmet
Sezgin, Gulbuz
Deveci, Ugur
Yener, Nese Arzu
Sinanoglu, Orhun
Source
Biochemistry Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cyclophosphamide (Cyc) is known to cause ovotoxicity and infertility in women.
Our aim is to investigate the possible ovotoxic effects of Cyc and possible antioxidant and protective effects of blue-green algae, Spirulina (Sp), in rat ovaries.
Eighteen rats were given: group I (n=6, control); group II (n=6, CP), a single dose Cyc; group III (n=6, Sp+Cyc), 7 days Sp+single dose Cyc.
Tissue malondialdehyde (MDA) levels, superoxide dismutase (SOD), and catalase (CAT) activities are assessed biochemically.
Normal and atretic primordial and primary follicle counts for all sections obtained for each ovary are calculated.
Mean number of follicle counts for each group are compared.
In Sp+Cyc group, tissue MDA levels were significantly lower than those in the CP and higher than those in the C group (CP>Sp+Cyc>C).
Tissue SOD activity was significantly higher in Sp+Cyc group than that in the CP group and lower than that in the C group (C>Sp+Cyc>C).
No statistically significant difference was found between the ovarian CAT activities in any group.
Histomorphometrically, there was also no significant difference between the mean numbers of normal and atretic small follicle counts.
Our results suggest that single dose Cyc has adverse effects on oxidant status of the ovaries and Sp has protective effects in Cyc-induced ovotoxicity.
American Psychological Association (APA)
Yener, Nese Arzu& Sinanoglu, Orhun& Ilter, Erdin& Celik, Aygen& Sezgin, Gulbuz& Midi, Ahmet…[et al.]. 2013. Effects of Spirulina on Cyclophosphamide-Induced Ovarian Toxicity in Rats : Biochemical and Histomorphometric Evaluation of the Ovary. Biochemistry Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-496964
Modern Language Association (MLA)
Yener, Nese Arzu…[et al.]. Effects of Spirulina on Cyclophosphamide-Induced Ovarian Toxicity in Rats : Biochemical and Histomorphometric Evaluation of the Ovary. Biochemistry Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-496964
American Medical Association (AMA)
Yener, Nese Arzu& Sinanoglu, Orhun& Ilter, Erdin& Celik, Aygen& Sezgin, Gulbuz& Midi, Ahmet…[et al.]. Effects of Spirulina on Cyclophosphamide-Induced Ovarian Toxicity in Rats : Biochemical and Histomorphometric Evaluation of the Ovary. Biochemistry Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-496964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496964