Differences in Epidural and Analgesic Use in Patients with Apparent Stage I Endometrial Cancer Treated by Open versus Laparoscopic Surgery : Results from the Randomised LACE Trial
Joint Authors
Obermair, Andreas
Janda, Monika
Baker, Jannah
Belavy, David
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
We compared postoperative analgesic requirements between women with early stage endometrial cancer treated by total abdominal hysterectomy (TAH) or total laparoscopic hysterectomy (TLH).
Methods.
760 patients with apparent stage I endometrial cancer were treated in the international, multicentre, prospective randomised trial (LACE) by TAH (n=353) or TLH (n=407) (2005–2010).
Epidural, opioid, and nonopioid analgesic requirements were collected until ten months after surgery.
Results.
Baseline demographics and analgesic use were comparable between treatment arms.
TAH patients were more likely to receive epidural analgesia than TLH patients (33% versus 0.5%, P<0.001) during the early postoperative phase.
Although opioid use was comparable in the TAH versus TLH groups during postoperative 0–2 days (99.7% versus 98.5%, P=0.09), a significantly higher proportion of TAH patients required opioids 3–5 days (70% versus 22%, P<0.0001), 6–14 days (35% versus 15%, P<0.0001), and 15–60 days (15% versus 9%, P=0.02) after surgery.
Mean pain scores were significantly higher in the TAH versus TLH group one (2.48 versus 1.62, P<0.0001) and four weeks (0.89 versus 0.63, P=0.01) following surgery.
Conclusion.
Treatment of early stage endometrial cancer with TLH is associated with less frequent use of epidural, lower post-operative opioid requirements, and better pain scores than TAH.
American Psychological Association (APA)
Baker, Jannah& Janda, Monika& Belavy, David& Obermair, Andreas. 2013. Differences in Epidural and Analgesic Use in Patients with Apparent Stage I Endometrial Cancer Treated by Open versus Laparoscopic Surgery : Results from the Randomised LACE Trial. Minimally Invasive Surgery،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-496976
Modern Language Association (MLA)
Baker, Jannah…[et al.]. Differences in Epidural and Analgesic Use in Patients with Apparent Stage I Endometrial Cancer Treated by Open versus Laparoscopic Surgery : Results from the Randomised LACE Trial. Minimally Invasive Surgery No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-496976
American Medical Association (AMA)
Baker, Jannah& Janda, Monika& Belavy, David& Obermair, Andreas. Differences in Epidural and Analgesic Use in Patients with Apparent Stage I Endometrial Cancer Treated by Open versus Laparoscopic Surgery : Results from the Randomised LACE Trial. Minimally Invasive Surgery. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-496976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496976