![](/images/graphics-bg.png)
Efficacy and Safety of Gwakhyangjeonggi-San Retention Enema in Normal Rats and Spontaneously Hypertensive Rats
Joint Authors
Song, Eunyoung
Park, Jaewoo
Lee, Euiju
Yoo, Junghee
Shin, Seungwon
Kwon, Jinhyeok
Bu, Yongmin
Lee, Junhee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The purpose of this study is to establish a protocol of retention-enema experiments and evaluate the antihypertensive effect and the safety of Gwakhyangjeonggi-san retention enema.
Normal and spontaneously hypertensive rats (SHRs) were divided into treatment and control groups, respectively.
We applied the Gwakhyangjeonggi-san extract by decoction and 0.9% NaCl in each group, estimated the blood pressure and body weight, and performed HPLC analysis.
ALT, AST, BUN, and creatinine were examined.
The systolic blood pressure within each group in normal rats differed significantly in time effect, and so did the diastolic blood pressure in the treatment group of normal rats.
The systolic, diastolic, and mean blood pressure showed significant differences in group effect in the treatment group of the SHRs.
The time effect of the body weight in both groups of normal rats differed significantly, so did group × time and time effects in both groups of SHRs.
AST, ALT, BUN, and creatinine showed no significant difference between groups.
We concluded that the Gwakhyangjeonggi-san retention enema has a hypotensive effect in normal rats within the regular range of blood pressure, but an antihypertensive effect in SHRs.
Also, the intervention is safe and does not affect the liver and kidney functions in normal rats.
American Psychological Association (APA)
Song, Eunyoung& Lee, Euiju& Bu, Yongmin& Lee, Junhee& Shin, Seungwon& Yoo, Junghee…[et al.]. 2013. Efficacy and Safety of Gwakhyangjeonggi-San Retention Enema in Normal Rats and Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497112
Modern Language Association (MLA)
Song, Eunyoung…[et al.]. Efficacy and Safety of Gwakhyangjeonggi-San Retention Enema in Normal Rats and Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-497112
American Medical Association (AMA)
Song, Eunyoung& Lee, Euiju& Bu, Yongmin& Lee, Junhee& Shin, Seungwon& Yoo, Junghee…[et al.]. Efficacy and Safety of Gwakhyangjeonggi-San Retention Enema in Normal Rats and Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497112