Xuezhikang Therapy Increases miR-33 Expression in Patients with Low HDL-C Levels
Joint Authors
Du, Guanhua
Cao, Ruihua
Ye, Ping
Sun, Lan
Zu, Mian
Zheng, Jin
Bai, Yongyi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
MicroRNA-33a and -b (miR-33a/b) have been revealed to be posttranscriptional regulators of HDL metabolism.
Xuezhikang (XZK) is a marked natural HDL-raising polypill.
We aim to evaluate the effects of XZK on the expression of circulating miR-33a/b in patients with low plasma HDL-C levels.
Methods.
A total of 42 participating patients with low baseline levels of HDL cholesterol were assigned to receive an XZK capsule, 600 mg twice daily for 6 months.
The expression of circulating miR-33a/b was detected at baseline and after XZK therapy measured with quantitative reverse-transcription (RT) polymerase chain reaction (PCR).
Results.
The mean (SD) HDL-C level after XZK treatment was 1.19 (0.13) mmol/L, representing an increase of 11.2% from baseline (P<0.001).
Q-PCR analysis of plasma miRNAs revealed an increase in relative miR-33a/b expression with XZK treatment.
The miR-33a expression was raised from 0.81 to 1.73 (P=0.012); miR-33b expression was increased from 1.2 to 2.75 (P<0.001).
The changes of miR-33a and miR-33b were inversely related to the posttreatment LDL-C levels (r=-0.37, P=0.019; r=-0.33, P=0.035, resp.).
Conclusion.
In patients with low HDL-C levels, XZK therapy raised plasma levels of miR-33a and miR-33b, which may inhibit cellular cholesterol export and limit the HDL-raising effect of XZK.
American Psychological Association (APA)
Cao, Ruihua& Bai, Yongyi& Sun, Lan& Zheng, Jin& Zu, Mian& Du, Guanhua…[et al.]. 2014. Xuezhikang Therapy Increases miR-33 Expression in Patients with Low HDL-C Levels. Disease Markers،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-497549
Modern Language Association (MLA)
Cao, Ruihua…[et al.]. Xuezhikang Therapy Increases miR-33 Expression in Patients with Low HDL-C Levels. Disease Markers No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-497549
American Medical Association (AMA)
Cao, Ruihua& Bai, Yongyi& Sun, Lan& Zheng, Jin& Zu, Mian& Du, Guanhua…[et al.]. Xuezhikang Therapy Increases miR-33 Expression in Patients with Low HDL-C Levels. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-497549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497549