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Clinical Outcomes after Treatment of Periodontal Intrabony Defects with Nanocrystalline Hydroxyapatite (Ostim) or Enamel Matrix Derivatives (Emdogain) : A Randomized Controlled Clinical Trial
Joint Authors
Hoffmann, Thomas
al-Machot, Elyan
Lorenz, Katrin
Noack, Barbara
Khalili, Ihssan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Periodontitis is an inflammatory process in response to dental biofilm and leads to periodontal tissue destruction.
The aim of this study was the comparison of outcomes using either an enamel matrix derivative (EMD) or a nanocrystalline hydroxyapatite (NHA) in regenerative periodontal therapy after 6 and 12 months.
Methods.
Using a parallel group, prospective randomized study design, we enrolled 19 patients in each group.
The primary outcome was bone fill after 12 months.
Attachment gain, probing pocket depth (PPD) reduction, and recession were secondary variables.
Additionally, early wound healing and adverse events were assessed.
Data analysis included test of noninferiority of NHA group (test) compared to EMD group (reference) in bone fill.
Differences in means of secondary variables were compared by paired t-test, frequency data by exact χ2 test.
Results.
Both groups showed significant bone fill, reduction of PPD, increase in recession, and gain of attachment after 6 and 12 months.
No significant differences between groups were found at any time point.
Adverse events were comparable between both groups with a tendency of more complaints in the NHA group.
Conclusion.
The clinical outcomes were similar in both groups.
EMD could have some advantage compared to NHA regarding patients comfort and adverse events.
The trial is registered with ClinicalTrials.gov NCT00757159.
American Psychological Association (APA)
al-Machot, Elyan& Hoffmann, Thomas& Lorenz, Katrin& Khalili, Ihssan& Noack, Barbara. 2014. Clinical Outcomes after Treatment of Periodontal Intrabony Defects with Nanocrystalline Hydroxyapatite (Ostim) or Enamel Matrix Derivatives (Emdogain) : A Randomized Controlled Clinical Trial. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-497996
Modern Language Association (MLA)
al-Machot, Elyan…[et al.]. Clinical Outcomes after Treatment of Periodontal Intrabony Defects with Nanocrystalline Hydroxyapatite (Ostim) or Enamel Matrix Derivatives (Emdogain) : A Randomized Controlled Clinical Trial. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-497996
American Medical Association (AMA)
al-Machot, Elyan& Hoffmann, Thomas& Lorenz, Katrin& Khalili, Ihssan& Noack, Barbara. Clinical Outcomes after Treatment of Periodontal Intrabony Defects with Nanocrystalline Hydroxyapatite (Ostim) or Enamel Matrix Derivatives (Emdogain) : A Randomized Controlled Clinical Trial. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-497996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497996