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Achyrocline satureioides (Lam.) D.C. Hydroalcoholic Extract Inhibits Neutrophil Functions Related to Innate Host Defense
Joint Authors
Cogliati, Bruno
Niero, Rivaldo
Wagner, Theodoro Marcel
Andrade, Sérgio Faloni de
Machado, Isabel Daufenback
Santin, José Roberto
Ferraz-de-Paula, Viviane
Barioni, Eric Diego
Farsky, Sandra Helena Poliselli
Machado, Marina da Silva
Rodrigues, Stephen Fernandes de Paula
Corrêa dos Santos, Matheus
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Achyrocline satureioides (Lam.) D.C.
is a herb native to South America, and its inflorescences are popularly employed to treat inflammatory diseases.
Here, the effects of the in vivo actions of the hydroalcoholic extract obtained from inflorescences of A.
satureioides on neutrophil trafficking into inflamed tissue were investigated.
Male Wistar rats were orally treated with A.
satureioides extract, and inflammation was induced one hour later by lipopolysaccharide injection into the subcutaneous tissue.
The number of leukocytes and the amount of chemotactic mediators were quantified in the inflammatory exudate, and adhesion molecule and toll-like receptor 4 (TLR-4) expressions and phorbol-myristate-acetate- (PMA-) stimulated oxidative burst were quantified in circulating neutrophils.
Leukocyte-endothelial interactions were quantified in the mesentery tissue.
Enzymes and tissue morphology of the liver and kidney were evaluated.
Treatment with A.
satureioides extract reduced neutrophil influx and secretion of leukotriene B4 and CINC-1 in the exudates, the number of rolling and adhered leukocytes in the mesentery postcapillary venules, neutrophil L-selectin, β2-integrin and TLR-4 expression, and oxidative burst, but did not cause an alteration in the morphology and activities of liver and kidney.
Together, the data show that A.
satureioides extract inhibits neutrophil functions related to the innate response and does not cause systemic toxicity.
American Psychological Association (APA)
Barioni, Eric Diego& Santin, José Roberto& Machado, Isabel Daufenback& Rodrigues, Stephen Fernandes de Paula& Ferraz-de-Paula, Viviane& Wagner, Theodoro Marcel…[et al.]. 2013. Achyrocline satureioides (Lam.) D.C. Hydroalcoholic Extract Inhibits Neutrophil Functions Related to Innate Host Defense. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-498125
Modern Language Association (MLA)
Barioni, Eric Diego…[et al.]. Achyrocline satureioides (Lam.) D.C. Hydroalcoholic Extract Inhibits Neutrophil Functions Related to Innate Host Defense. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-498125
American Medical Association (AMA)
Barioni, Eric Diego& Santin, José Roberto& Machado, Isabel Daufenback& Rodrigues, Stephen Fernandes de Paula& Ferraz-de-Paula, Viviane& Wagner, Theodoro Marcel…[et al.]. Achyrocline satureioides (Lam.) D.C. Hydroalcoholic Extract Inhibits Neutrophil Functions Related to Innate Host Defense. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-498125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498125