Physical Activity and Telomere Biology : Exploring the Link with Aging-Related Disease Prevention
Joint Authors
Roth, Stephen M.
Ludlow, Andrew T.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Physical activity is associated with reduced risk of several age-related diseases as well as with increased longevity in both rodents and humans.
Though these associations are well established, evidence of the molecular and cellular factors associated with reduced disease risk and increased longevity resulting from physical activity is sparse.
A long-standing hypothesis of aging is the telomere hypothesis: as a cell divides, telomeres shorten resulting eventually in replicative senescence and an aged phenotype.
Several reports have recently associated telomeres and telomere-related proteins to diseases associated with physical inactivity and aging including cardiovascular disease, insulin resistance, and hypertension.
Interestingly several reports have also shown that longer telomeres are associated with higher physical activity levels, indicating a potential mechanistic link between physical activity, reduced age-related disease risk, and longevity.
The primary purpose of this review is to discuss the potential importance of physical activity in telomere biology in the context of inactivity- and age-related diseases.
A secondary purpose is to explore potential mechanisms and important avenues for future research in the field of telomeres and diseases associated with physical inactivity and aging.
American Psychological Association (APA)
Ludlow, Andrew T.& Roth, Stephen M.. 2011. Physical Activity and Telomere Biology : Exploring the Link with Aging-Related Disease Prevention. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-498286
Modern Language Association (MLA)
Ludlow, Andrew T.& Roth, Stephen M.. Physical Activity and Telomere Biology : Exploring the Link with Aging-Related Disease Prevention. Journal of Aging Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-498286
American Medical Association (AMA)
Ludlow, Andrew T.& Roth, Stephen M.. Physical Activity and Telomere Biology : Exploring the Link with Aging-Related Disease Prevention. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-498286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498286