Potential Benefits on Impairment of Endothelial Function after a High-Fat Meal of 4 Weeks of Flavonoid Supplementation
Joint Authors
Barringer, T. A.
Hatcher, L.
Sasser, H. C.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Studies with foods high in flavonoids have demonstrated improvement in endothelial function.
We investigated whether 4 weeks of flavonoid supplementation would prevent an adverse impact on endothelial function of a high-fat meal.
Endothelial function was measured by reactive hyperemia peripheral arterial tonometry (RH-PAT).
The RH-PAT index was measured both before and 3 h after a high-fat meal, in 23 healthy volunteers.
Subjects were randomized in a double-blind, cross-over design to 4 weeks of daily supplementation with OPC-3, or a matching placebo.
RH-PAT index before and after the high-fat meal was measured at the beginning and end of each 4-week treatment phase.
The high-fat meal caused a decline in endothelial function at baseline in the placebo (-10.71%, P = .006) and flavonoid [-9.97% (P = .077)] groups, and there was no difference in decline between arms (P = .906).
The high-fat meal produced a decline after 4 weeks of placebo [-12.37% (P = .005)], but no decline after 4 weeks of flavonoid supplement [-3.16% (P = .663)], and the difference between the two responses was highly significant (P < .0001).
Within-group comparisons revealed no difference in endothelial function decline in the placebo arm between baseline and 4 weeks [-10.71% versus -12.37% (P = .758)].
In the flavonoid supplement arm, the difference in endothelial function decline between baseline and 4 weeks was -9.97% versus -3.16%, but did not reach statistical significance (P = .451).
These results suggest that the flavonoid supplement used in this study mitigates the impairment of endothelial function caused by a high-fat meal.
Whether certain subpopulations derive greater or lesser benefit remains unclear.
American Psychological Association (APA)
Barringer, T. A.& Hatcher, L.& Sasser, H. C.. 2011. Potential Benefits on Impairment of Endothelial Function after a High-Fat Meal of 4 Weeks of Flavonoid Supplementation. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-498894
Modern Language Association (MLA)
Barringer, T. A.…[et al.]. Potential Benefits on Impairment of Endothelial Function after a High-Fat Meal of 4 Weeks of Flavonoid Supplementation. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-498894
American Medical Association (AMA)
Barringer, T. A.& Hatcher, L.& Sasser, H. C.. Potential Benefits on Impairment of Endothelial Function after a High-Fat Meal of 4 Weeks of Flavonoid Supplementation. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-498894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498894