Potential Anticancer Properties of Grape Antioxidants
Joint Authors
Zhou, Kequan
Raffoul, Julian J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Dietary intake of foods rich in antioxidant properties is suggested to be cancer protective.
Foods rich in antioxidant properties include grape (Vitis vinifera), one of the world’s largest fruit crops and most commonly consumed fruits in the world.
The composition and cancer-protective effects of major phenolic antioxidants in grape skin and seed extracts are discussed in this review.
Grape skin and seed extracts exert strong free radical scavenging and chelating activities and inhibit lipid oxidation in various food and cell models in vitro.
The use of grape antioxidants are promising against a broad range of cancer cells by targeting epidermal growth factor receptor (EGFR) and its downstream pathways, inhibiting over-expression of COX-2 and prostaglandin E2 receptors, or modifying estrogen receptor pathways, resulting in cell cycle arrest and apoptosis.
Interestingly, some of these activities were also demonstrated in animal models.
However, in vivo studies have demonstrated inconsistent antioxidant efficacy.
Nonetheless, a growing body of evidence from human clinical trials has demonstrated that consumption of grape, wine and grape juice exerts many health-promoting and possible anti-cancer effects.
Thus, grape skin and seed extracts have great potential in cancer prevention and further investigation into this exciting field is warranted.
American Psychological Association (APA)
Zhou, Kequan& Raffoul, Julian J.. 2012. Potential Anticancer Properties of Grape Antioxidants. Journal of Oncology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499285
Modern Language Association (MLA)
Zhou, Kequan& Raffoul, Julian J.. Potential Anticancer Properties of Grape Antioxidants. Journal of Oncology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-499285
American Medical Association (AMA)
Zhou, Kequan& Raffoul, Julian J.. Potential Anticancer Properties of Grape Antioxidants. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499285