A Normal Range of KL-6MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography
Joint Authors
Ebina, Masahito
Chiba, Shigeki
Ohta, Hiromitsu
Hisata, Shu
Ono, Shuichi
Nukiwa, Toshihiro
Kimura, Yuichiro
Kobayashi, Takao
Shibata, Naoko
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical outcomes based on their independent effects are not known.
Eleven asymptomatic patients, detected with honeycombing on high-resolution computed tomography (HRCT), were compared with 17 other IPF outpatients having slight respiratory symptoms and honeycombing as well.
Although SP-D was increased in both groups, KL-6 was significantly higher in the symptomatic IPF group.
When the patients (n=11) having both biomarkers elevated were compared with the other patients (n=6) with only SP-D elevated, the distribution of fibrotic lesions with honeycombing on HRCT was larger and the survival time was shorter in the patients having both biomarkers elevated.
Immunohistochemical analysis also differentiated these biomarkers in the lung.
These results suggest both a cause and the prognostic value of dissociation of these biomarkers.
American Psychological Association (APA)
Hisata, Shu& Kimura, Yuichiro& Shibata, Naoko& Ono, Shuichi& Kobayashi, Takao& Chiba, Shigeki…[et al.]. 2010. A Normal Range of KL-6MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography. Pulmonary Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-499516
Modern Language Association (MLA)
Hisata, Shu…[et al.]. A Normal Range of KL-6MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography. Pulmonary Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-499516
American Medical Association (AMA)
Hisata, Shu& Kimura, Yuichiro& Shibata, Naoko& Ono, Shuichi& Kobayashi, Takao& Chiba, Shigeki…[et al.]. A Normal Range of KL-6MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography. Pulmonary Medicine. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-499516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499516
