The Effects of New Alibernet Red Wine Extract on Nitric Oxide and Reactive Oxygen Species Production in Spontaneously Hypertensive Rats
Joint Authors
Pecháňová, Olga
Ševčík, Rudolf
Vranková, Stanislava
Dovinová, Ima
Barta, Andrej
Parohová, Jana
Kovacsová, Maria
Kondrashov, Alexey
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
We aimed to perform a chemical analysis of both Alibernet red wine and an alcohol-free Alibernet red wine extract (AWE) and to investigate the effects of AWE on nitric oxide and reactive oxygen species production as well as blood pressure development in normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHRs).
Total antioxidant capacity together with total phenolic and selected mineral content was measured in wine and AWE.
Young 6-week-old male WKY and SHR were treated with AWE (24,2 mg/kg/day) for 3 weeks.
Total NOS and SOD activities, eNOS and SOD1 protein expressions, and superoxide production were determined in the tissues.
Both antioxidant capacity and phenolic content were significantly higher in AWE compared to wine.
The AWE increased NOS activity in the left ventricle, aorta, and kidney of SHR, while it did not change NOS activity in WKY rats.
Similarly, increased SOD activity in the plasma and left ventricle was observed in SHR only.
There were no changes in eNOS and SOD1 expressions.
In conclusion, phenolics and minerals included in AWE may contribute directly to increased NOS and SOD activities of SHR.
Nevertheless, 3 weeks of AWE treatment failed to affect blood pressure of SHR.
American Psychological Association (APA)
Kondrashov, Alexey& Vranková, Stanislava& Dovinová, Ima& Ševčík, Rudolf& Parohová, Jana& Barta, Andrej…[et al.]. 2012. The Effects of New Alibernet Red Wine Extract on Nitric Oxide and Reactive Oxygen Species Production in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499549
Modern Language Association (MLA)
Kondrashov, Alexey…[et al.]. The Effects of New Alibernet Red Wine Extract on Nitric Oxide and Reactive Oxygen Species Production in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-499549
American Medical Association (AMA)
Kondrashov, Alexey& Vranková, Stanislava& Dovinová, Ima& Ševčík, Rudolf& Parohová, Jana& Barta, Andrej…[et al.]. The Effects of New Alibernet Red Wine Extract on Nitric Oxide and Reactive Oxygen Species Production in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499549