Cyclooxygenase Inhibitor Associated with Carboplatin in Treatment of Metastatic Nasal Carcinoma in Dog
Joint Authors
Gouveia Calazans, Sabryna
Fonseca-Alves, Carlos Eduardo
Gonçalves Corrêa, Aline
Elias, Fabiana
Source
Journal of Applied Mathematics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 10-year-old, intact male, pinscher was presented with unilateral bloodstained nasal discharge, sneezing, dyspnea, zygomatic arch deformity, submandibular lymph node increase, blindness in right eye, and exophthalmia.
After clinical examination, it was found that the animal presented with upper respiratory tract dyspnea origin, possibly caused by an obstructive process.
Complete blood count (CBC), ocular ultrasonography, thoracic radiographs, mandibular lymph node, and nasal sinus fine needle aspiration were performed.
The right mandibular lymph node excisional biopsy was conducted and a tumor sample was obtained through the nasal fistula at hard palate.
The material was processed, paraffin embedded, sectioned, and stained with hematoxylin and eosin.
Immunohistochemical staining for cytokeratin (AE1/AE3), vimentin, and COX-2 was performed.
After histopathological evaluation nasal carcinoma diagnosis was obtained.
Chemotherapy was established with carboplatin 300 mg/m2 intravenously—four cycles with intervals of 21 days—and firocoxib 5 mg/kg orally every 24 hours for 7 months.
After 7 months the treatment started, the animal presented with ataxia, vocalization, hyperesthesia, and anorexia.
Due the clinical condition presented, the animal owner opted for performing euthanasia.
The chemotherapy protocol was effective causing the disease stagnation, minimizing the clinical signs, and extending patient survival and quality of life.
American Psychological Association (APA)
Fonseca-Alves, Carlos Eduardo& Gonçalves Corrêa, Aline& Elias, Fabiana& Gouveia Calazans, Sabryna. 2014. Cyclooxygenase Inhibitor Associated with Carboplatin in Treatment of Metastatic Nasal Carcinoma in Dog. Journal of Applied Mathematics،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-500535
Modern Language Association (MLA)
Fonseca-Alves, Carlos Eduardo…[et al.]. Cyclooxygenase Inhibitor Associated with Carboplatin in Treatment of Metastatic Nasal Carcinoma in Dog. Journal of Applied Mathematics No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-500535
American Medical Association (AMA)
Fonseca-Alves, Carlos Eduardo& Gonçalves Corrêa, Aline& Elias, Fabiana& Gouveia Calazans, Sabryna. Cyclooxygenase Inhibitor Associated with Carboplatin in Treatment of Metastatic Nasal Carcinoma in Dog. Journal of Applied Mathematics. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-500535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500535