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An Association between Bevacizumab and Recurrent Posterior Reversible Encephalopathy Syndrome in a Patient Presenting with Deep Vein Thrombosis : A Case Report and Review of the Literature
Joint Authors
Lazarus, Mark
Amundson, Stanley
Belani, Rajesh
Source
Case Reports in Oncological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
The posterior reversible encephalopathy syndrome (PRES) is a syndrome characterized by hypertension, headache, seizures, and visual disturbances.
Causes of PRES include preeclampsia/eclampsia, hypertension, and recently bevacizumab, a monoclonal antibody vascular endothelial growth factor (VEGF) inhibitor.
There is no information to date about PRES recurrence in patients taking bevacizumab or descriptions of deep vein thrombosis (DVT) in the setting of PRES.
We reviewed data on a patient receiving bevacizumab who presented with a DVT and PRES and later developed recurrent PRES.
Case.
A 72-year-old man with metastatic pulmonary adenocarcinoma received maintenance bevacizumab following six cycles of carboplatin and paclitaxel.
Following his eighth dose of bevacizumab, he developed a DVT as well as PRES.
He made a rapid recovery and was discharged from the hospital but went on to develop PRES recurrence nine days following his original episode.
Conclusion.
Several mechanisms exist whereby exposure to bevacizumab could be related to the development of both DVT and PRES by inducing global endothelial dysfunction.
Recurrent PRES may result from bevacizumab’s prolonged half-life (11–50 days) and suboptimal blood pressure control.
In the setting of bevacizumab, PRES surveillance may play a similar role in preeclampsia screening as both diseases share similar antiangiogenic signaling pathways.
American Psychological Association (APA)
Lazarus, Mark& Amundson, Stanley& Belani, Rajesh. 2012. An Association between Bevacizumab and Recurrent Posterior Reversible Encephalopathy Syndrome in a Patient Presenting with Deep Vein Thrombosis : A Case Report and Review of the Literature. Case Reports in Oncological Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-500682
Modern Language Association (MLA)
Lazarus, Mark…[et al.]. An Association between Bevacizumab and Recurrent Posterior Reversible Encephalopathy Syndrome in a Patient Presenting with Deep Vein Thrombosis : A Case Report and Review of the Literature. Case Reports in Oncological Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-500682
American Medical Association (AMA)
Lazarus, Mark& Amundson, Stanley& Belani, Rajesh. An Association between Bevacizumab and Recurrent Posterior Reversible Encephalopathy Syndrome in a Patient Presenting with Deep Vein Thrombosis : A Case Report and Review of the Literature. Case Reports in Oncological Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-500682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500682