Proteomics of Uveal Melanoma : A Minireview
Joint Authors
Vorum, Henrik
Abildgaard, Søren K. O.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Uveal melanoma (UM) continues to be associated with a high mortality rate of up to 50% due to metastatic spread primarily to the liver.
Currently there are relatively effective treatments for the primary tumor, though the management of the metastatic disease remains inadequate.
Conventional diagnostic tools have a low sensitivity for detecting metastasis, and early detection of metastatic spread would allow more treatment options that could ultimately increase survival of UM patients.
Advanced proteomic methods have already helped to find potential biomarkers associated with UM pathogenesis and metastasis.
In the present review we discuss the field of proteomics in relation to studies elucidating biomarkers of UM, where proteins such as S-100β, osteopontin (OPN), and melanoma inhibitory activity (MIA) have been shown to be associated with metastasis.
American Psychological Association (APA)
Abildgaard, Søren K. O.& Vorum, Henrik. 2013. Proteomics of Uveal Melanoma : A Minireview. Journal of Oncology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-500804
Modern Language Association (MLA)
Abildgaard, Søren K. O.& Vorum, Henrik. Proteomics of Uveal Melanoma : A Minireview. Journal of Oncology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-500804
American Medical Association (AMA)
Abildgaard, Søren K. O.& Vorum, Henrik. Proteomics of Uveal Melanoma : A Minireview. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-500804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500804