![](/images/graphics-bg.png)
Radiation Therapy in Addition to Gross Total Resection of Retroperitoneal Sarcoma Results in Prolonged Survival : Results from a Single Institutional Study
Joint Authors
Kinsella, Timothy J.
Zagar, Timothy M.
Kim, Julian A.
Chen, William C.
Kunos, Charles A.
Shenk, Robert R.
Abdul-Karim, Fadi W.
Seo, Yuji
Harpp, Deb
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
Typical treatment of retroperitoneal sarcomas (RPSs) is surgery with or without radiation therapy for localized disease.
With surgery alone, local failure rates are as high as 90%; this led to radiation therapy playing an important role in the treatment of RPSs.
Methods.
Thirty-one patients with retroperitoneal sarcoma treated with gross total resection and radiation therapy make up this retrospective analysis.
Nineteen were treated preoperatively and 12 postoperatively (median dose, 59.4 Gy)—sixteen also received intraoperative radiation therapy (IORT) (median dose, 11 Gy).
Patients were followed with stringent regimens, including frequent CT scans of the chest, abdomen, and pelvis.
Results.
With a median follow-up of 19 months (range 1–66 months), the 2-year overall survival (OS) rate is 70% (median, 52 months).
The 2-year locoregional control (LRC) rate is 77% (median, 61.6 months).
The 2-year distant disease free survival (DDFS) rate is 70% (median not reached).
There were no differences in radiation-related acute and late toxicities among patients treated pre- versus postoperatively, whether with or without IORT.
Conclusions.
Compared to surgery alone, neoadjuvant or adjuvant radiation therapy offers patients with RPS an excellent chance for long-term LRC, DDS, and OS.
The integration of modern treatment planning for external beam radiation therapy and IORT allows for higher doses to be delivered with acceptable toxicities.
American Psychological Association (APA)
Zagar, Timothy M.& Shenk, Robert R.& Kim, Julian A.& Harpp, Deb& Kunos, Charles A.& Abdul-Karim, Fadi W.…[et al.]. 2009. Radiation Therapy in Addition to Gross Total Resection of Retroperitoneal Sarcoma Results in Prolonged Survival : Results from a Single Institutional Study. Journal of Oncology،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-501019
Modern Language Association (MLA)
Zagar, Timothy M.…[et al.]. Radiation Therapy in Addition to Gross Total Resection of Retroperitoneal Sarcoma Results in Prolonged Survival : Results from a Single Institutional Study. Journal of Oncology No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-501019
American Medical Association (AMA)
Zagar, Timothy M.& Shenk, Robert R.& Kim, Julian A.& Harpp, Deb& Kunos, Charles A.& Abdul-Karim, Fadi W.…[et al.]. Radiation Therapy in Addition to Gross Total Resection of Retroperitoneal Sarcoma Results in Prolonged Survival : Results from a Single Institutional Study. Journal of Oncology. 2009. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-501019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501019