Effect of Korean Herbal Medicine Combined with a Probiotic Mixture on Diarrhea-Dominant Irritable Bowel Syndrome : A Double-Blind, Randomized, Placebo-Controlled Trial
Joint Authors
Chung, Won-Seok
Park, Jae-Woo
Kim, Seul-Ki
Lee, Beom-Joon
Ryu, Bongha
Seo, Jae-gu
Kim, Jinsung
Lee, Jin-Moo
Han, Gajin
Yeo, Inkwon
Ko, Seok-Jae
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Although combination therapy with herbal medicine and probiotics is gaining popularity for controlling diarrhea-dominant irritable bowel syndrome (D-IBS) symptoms, few studies have investigated its clinical effects.
Materials and Methods.
Fifty-three patients with D-IBS were randomly allocated into 1 of the following 4 groups: herbal medicine (Gwakhyangjeonggisan; GJS) plus probiotics (Duolac7S; DUO), GJS plus placebo DUO, placebo GJS plus DUO, and placebo GJS plus placebo DUO.
The study period consisted of a 2-week run-in, 8 weeks of administration, and 2 weeks of follow-up.
The primary outcomes were weekly adequate relief (AR) of overall IBS symptoms and the proportion of responders (PR) during the administration period.
The secondary outcomes included individual IBS symptoms, stool assessment, and quality of life.
Changes of intestinal microbiota and intestinal permeability were also analyzed.
Results and Discussion.
Weekly AR was not different among the 4 groups throughout the treatment period.
However, the 3 treatment groups exhibited significant improvements in PR compared to the findings in the placebo group.
In the intestinal microbiota assessment, herbal medicine and probiotics synergistically increased beneficial bacteria counts.
Conclusion.
Combination therapy with herbal medicine and probiotics appears to relieve overall IBS symptoms by synergistically increasing beneficial intestinal microbe counts.
American Psychological Association (APA)
Ko, Seok-Jae& Han, Gajin& Kim, Seul-Ki& Seo, Jae-gu& Chung, Won-Seok& Ryu, Bongha…[et al.]. 2013. Effect of Korean Herbal Medicine Combined with a Probiotic Mixture on Diarrhea-Dominant Irritable Bowel Syndrome : A Double-Blind, Randomized, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-501067
Modern Language Association (MLA)
Ko, Seok-Jae…[et al.]. Effect of Korean Herbal Medicine Combined with a Probiotic Mixture on Diarrhea-Dominant Irritable Bowel Syndrome : A Double-Blind, Randomized, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-501067
American Medical Association (AMA)
Ko, Seok-Jae& Han, Gajin& Kim, Seul-Ki& Seo, Jae-gu& Chung, Won-Seok& Ryu, Bongha…[et al.]. Effect of Korean Herbal Medicine Combined with a Probiotic Mixture on Diarrhea-Dominant Irritable Bowel Syndrome : A Double-Blind, Randomized, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-501067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501067