Sarcopenic Obesity and Cognitive Functioning : The Mediating Roles of Insulin Resistance and Inflammation?
Joint Authors
Levine, M. E.
Crimmins, Eileen M.
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study examined the influence of insulin resistance and inflammation on the association between body composition and cognitive performance in older adults, aged 60–69 and aged 70 and older.
Subjects included 1127 adults from NHANES 1999–2002.
Body composition was categorized based on measurements of muscle mass and waist circumference as sarcopenic nonobese, nonsarcopenic obese, sarcopenic obese, and normal.
Using OLS regression models, our findings suggest body composition is not associated with cognitive functioning in adults ages 60–69; however, for adults aged 70 and over, sarcopenia and obesity, either independently or concurrently, were associated with worse cognitive functioning relative to non-sarcopenic non-obese older adults.
Furthermore, insulin resistance accounted for a significant proportion of the relationship between cognitive performance and obesity, with or without sarcopenia.
Additionally, although high CRP was significantly associated with poorer cognitive functioning in adults ages 60–69, it did not influence the association between body composition and cognitive performance.
This study provides evidence that age-related physiological maladaptations, such as metabolic deregulation, which are associated with abdominal fat, may simultaneously contribute to lower cognition and muscle mass, reflecting a degradation of multiple physiological systems.
American Psychological Association (APA)
Levine, M. E.& Crimmins, Eileen M.. 2012. Sarcopenic Obesity and Cognitive Functioning : The Mediating Roles of Insulin Resistance and Inflammation?. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-501224
Modern Language Association (MLA)
Levine, M. E.& Crimmins, Eileen M.. Sarcopenic Obesity and Cognitive Functioning : The Mediating Roles of Insulin Resistance and Inflammation?. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-501224
American Medical Association (AMA)
Levine, M. E.& Crimmins, Eileen M.. Sarcopenic Obesity and Cognitive Functioning : The Mediating Roles of Insulin Resistance and Inflammation?. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-501224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501224