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Weight Loss and Melatonin Reduce Obesity-Induced Oxidative Damage in Rat Testis
Joint Authors
Erdemir, Fikret
Uluocak, Nihat
Atılgan, Doğan
Markoc, Fatma
Parlaktas, Bekir Suha
Ozyurt, Huseyin
Erkorkmaz, Unal
Kilic, Sahin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
We aimed to evaluate the antioxidant effects of weight loss and melatonin on the obesity-induced oxidative damage in rat testes.
Materials and Methods.
28 male Wistar albino rats were randomly divided into 4 groups, each consisting of 7 rats: control group (Group 1), obesity group (Group 2), obesity + MLT group (Group 3), and weight loss group (Group 4).
Rats were weighed at the beginning and at the end of the study.
Bilateral orchiectomy was performed and 5 cc blood samples were obtained from all of the rats.
Superoxide dismutase (SOD), malondialdehyde (MDA), and protein carbonyl (PC) levels were analysed in the testicular tissues and serum.
Spermatogenesis was evaluated with the Johnsen scoring system.
Results.
The testicular tissue and serum levels of MDA, PC, and SOD activity were increased in the obesity group in comparison to the sham operated group (P<0.05).
Weight loss and melatonin treatment ameliorated MDA, PC, and SOD levels in testicular tissue and serum significantly (P<0.05).
There was no significant difference between groups in terms of mean Johnsen score (P=0.727).
Conclusion.
Experimentally created obesity caused oxidative stress and both melatonin and weight loss reduced oxidative stress parameters in rat testes.
American Psychological Association (APA)
Atılgan, Doğan& Parlaktas, Bekir Suha& Uluocak, Nihat& Erdemir, Fikret& Kilic, Sahin& Erkorkmaz, Unal…[et al.]. 2013. Weight Loss and Melatonin Reduce Obesity-Induced Oxidative Damage in Rat Testis. Advances in Urology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-501988
Modern Language Association (MLA)
Atılgan, Doğan…[et al.]. Weight Loss and Melatonin Reduce Obesity-Induced Oxidative Damage in Rat Testis. Advances in Urology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-501988
American Medical Association (AMA)
Atılgan, Doğan& Parlaktas, Bekir Suha& Uluocak, Nihat& Erdemir, Fikret& Kilic, Sahin& Erkorkmaz, Unal…[et al.]. Weight Loss and Melatonin Reduce Obesity-Induced Oxidative Damage in Rat Testis. Advances in Urology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-501988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501988