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A Metabolomics-Based Strategy for the Quality Control of Traditional Chinese Medicine : Shengmai Injection as a Case Study
Joint Authors
Xie, Guoxiang
Jia, Wei
Chen, Huiyuan
Li, Xiaodong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Quality control of traditional Chinese medicines (TCMs) used clinically is becoming a challenge and has limited the development of TCM due to the high variability in concentration levels of active ingredients and markers as well as the lack of well-established criteria.
Using Shengmai injection, which is a well-established TCM, as an example, we developed an integrated profiling approach that simultaneously captures the entire spectrum of ingredients and quantitatively determines the levels of seven key ingredients in the TCM product.
A multivariate statistical model was constructed to establish a “seven-marker-” based quality standard that qualified the majority of samples in this study.
This newly developed strategy showed that a panel of key ingredients or markers in the TCM product were relatively consistent within a statistically acceptable range.
Therefore, this metabolomics-based approach will complement the current quality control standard using the concentration of several key ingredients or their total content and help improve the consistency and clinic efficacy of TCM products.
American Psychological Association (APA)
Li, Xiaodong& Chen, Huiyuan& Jia, Wei& Xie, Guoxiang. 2013. A Metabolomics-Based Strategy for the Quality Control of Traditional Chinese Medicine : Shengmai Injection as a Case Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501995
Modern Language Association (MLA)
Li, Xiaodong…[et al.]. A Metabolomics-Based Strategy for the Quality Control of Traditional Chinese Medicine : Shengmai Injection as a Case Study. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-501995
American Medical Association (AMA)
Li, Xiaodong& Chen, Huiyuan& Jia, Wei& Xie, Guoxiang. A Metabolomics-Based Strategy for the Quality Control of Traditional Chinese Medicine : Shengmai Injection as a Case Study. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501995