Immunotherapy Responsive Autoimmune Subacute Encephalitis : A Report of Two Cases
Joint Authors
Lynch, Sharon G.
Mittal, Manoj
Hammond, Nancy
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
To describe the clinical characteristics and radiological findings in two patients with subacute encephalitis associated with elevated serum voltage-gated potassium channel antibody (VGKCAb) and antithyroperoxidase (TPO) antibody.
Case Reports.
Case 1: 63-year-old woman was admitted for altered mental status and possible seizure activity.
MRI brain showed hyperintensity in the bilateral hippocampal areas.
She was positive for VGKCAb and anti-TPO antibodies.
She was treated with steroids, IVIG, plasma exchange and azathioprine.
After 8 months, she had marked improvement in her memory and seizures.
Case 2: 61-year-old woman was admitted for video EEG monitoring of unclassified seizure and cognitive function decline.
MRI of the brain showed mild hyperintensity in bilateral hippocampal areas and significant atrophy in the frontotemporal lesion.
Anti-TPO antibody and VGKCAb were positive.
She was treated with steroids, plasma exchange and azathioprine.
After 9 months, she had marked improvement in her memory and seizures.
Conclusion.
Autoimmune subacute encephalitis appears to be an underdiagnosed entity.
It is important to screen patients with subacute encephalitis for anti-TPO antibody and VGKCAb, particularly in the presence of seizures.
Immunosuppressive therapy appears to be effective in treating this entity.
American Psychological Association (APA)
Mittal, Manoj& Hammond, Nancy& Lynch, Sharon G.. 2010. Immunotherapy Responsive Autoimmune Subacute Encephalitis : A Report of Two Cases. Case Reports in Medicine،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-502104
Modern Language Association (MLA)
Mittal, Manoj…[et al.]. Immunotherapy Responsive Autoimmune Subacute Encephalitis : A Report of Two Cases. Case Reports in Medicine No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-502104
American Medical Association (AMA)
Mittal, Manoj& Hammond, Nancy& Lynch, Sharon G.. Immunotherapy Responsive Autoimmune Subacute Encephalitis : A Report of Two Cases. Case Reports in Medicine. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-502104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502104