dTGS : Method for Effective Components Identification from Traditional Chinese Medicine Formula and Mechanism Analysis
Joint Authors
Wu, Yi
Ren, Yinglong
Wang, Yun
Gu, Hao
Luo, Ji
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Because of the complexity of the components in Traditional Chinese Medicine formula (TCM formula), it is still a challenge to identify its effective components, to elucidate the mechanism of the components, and to discover the relationship between components and therapy objectives.
In this paper, a method called directed TCM grammar systems (dTGS) for effective component identification was proposed using entity grammar systems (EGS) as the theoretical framework.
The component-disease relationship of a TCM formula (i.e., Bai-Hu decoction plus Wasting-Thirsting formula, BHDWT) and one disease (i.e., type 2 diabetes mellitus) treated with it was studied, and the effective component groups (ECGs) were identified.
19 compounds were found acting on 20 proteins in type 2 diabetes mellitus (T2D) disease network, and 15 compounds were determined as the candidate effective components.
Results indicated that this method can be used to identify the effective components and provide an innovative way to elucidate the molecular mechanism of TCM formulas.
American Psychological Association (APA)
Luo, Ji& Ren, Yinglong& Gu, Hao& Wu, Yi& Wang, Yun. 2013. dTGS : Method for Effective Components Identification from Traditional Chinese Medicine Formula and Mechanism Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-502392
Modern Language Association (MLA)
Luo, Ji…[et al.]. dTGS : Method for Effective Components Identification from Traditional Chinese Medicine Formula and Mechanism Analysis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-502392
American Medical Association (AMA)
Luo, Ji& Ren, Yinglong& Gu, Hao& Wu, Yi& Wang, Yun. dTGS : Method for Effective Components Identification from Traditional Chinese Medicine Formula and Mechanism Analysis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-502392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502392