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Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine : Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry
Joint Authors
Filipsson Nyström, Helena
Lausmaa, Jukka
Jansson, Svante
Berg, Gertrud
Hansson, Marie
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Patients with Graves' disease can be medically prepared before surgery in different ways, which may have various effects on iodine stores.
Thyroid specimens were collected at surgery from two patients pretreated with propylthiouracil (PTU) and stable iodine, respectively.
A quantitative analysis of iodine content was performed using X-ray fluorescence (XRF) in frozen tissue and a qualitative analysis of aldehyde-fixed material with Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS).
Iodine concentrations were 0.9 mg/mL and 0.5 mg/mL in the thyroid tissue from the patients treated with PTU and stable iodine respectively.
TOF-SIMS showed iodine in the follicle lumina in both.
However, in the PTU case, iodine was also seen within the thyrocytes indicating accumulation of iodinated compounds from uninhibited hormone release.
XRF and TOF-SIMS can be used to follow iodine distribution within the thyroid and the intricate processes following the different medical treatment alternatives in Graves' disease.
American Psychological Association (APA)
Hansson, Marie& Filipsson Nyström, Helena& Jansson, Svante& Lausmaa, Jukka& Berg, Gertrud. 2012. Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine : Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry. Case Reports in Endocrinology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-502581
Modern Language Association (MLA)
Hansson, Marie…[et al.]. Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine : Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry. Case Reports in Endocrinology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-502581
American Medical Association (AMA)
Hansson, Marie& Filipsson Nyström, Helena& Jansson, Svante& Lausmaa, Jukka& Berg, Gertrud. Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine : Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry. Case Reports in Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-502581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502581