Evaluation of Assays for Measurement of Serum (Anti)oxidants in Hemodialysis Patients
Joint Authors
Ruskovska, Tatjana
Antarorov, Risto
Jansen, Eugene H. J. M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Various biomarkers and assays have been used for assessment of (anti)oxidant status in hemodialysis patients, including those intended for measurement of serum total (anti)oxidants, most often as a part of panel biomarkers.
Methods.
Serum (anti)oxidant status was measured in 32 chronically hemodialyzed patients and in 47 healthy persons, using two oxidations and three antioxidant assays.
Results.
The patients before the hemodialysis session have had higher values of total oxidants in comparison to the healthy persons, with a further increase during the hemodialysis.
These findings were confirmed with both oxidation assays, but they differ in the percentage of increase and the statistical significance.
All three antioxidant assays showed significantly higher values of the total serum antioxidants in the patients before the hemodialysis session in comparison to the healthy persons, and their significant decrease during the hemodialysis.
However, the assays differ in the percentage of decrease, its statistical significance, and the correlations with uric acid.
Conclusion.
The variability of results of total (anti)oxidants which are obtained using different assays should be taken into account when interpreting data from clinical studies of oxidative stress, especially in complex pathologies such as chronic hemodialysis.
American Psychological Association (APA)
Ruskovska, Tatjana& Jansen, Eugene H. J. M.& Antarorov, Risto. 2014. Evaluation of Assays for Measurement of Serum (Anti)oxidants in Hemodialysis Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-502681
Modern Language Association (MLA)
Ruskovska, Tatjana…[et al.]. Evaluation of Assays for Measurement of Serum (Anti)oxidants in Hemodialysis Patients. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-502681
American Medical Association (AMA)
Ruskovska, Tatjana& Jansen, Eugene H. J. M.& Antarorov, Risto. Evaluation of Assays for Measurement of Serum (Anti)oxidants in Hemodialysis Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-502681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502681