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Vitamins E and C Alleviate the Germ Cell Loss and Oxidative Stress in Cryptorchidism When Administered Separately but Not When Combined in Rats
Joint Authors
Afolabi, Ayobami Oladele
Alagbonsi, Isiaka Abdullateef
Olotu, Olaolu Opeyemi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The antioxidant effects of vitamins C and E on cryptorchidism-induced oxidative stress were investigated in male Sprague-Dawley rats.
Forty rats (200–250 g) were randomly divided in a blinded fashion into five groups (n=8).
Group 1 was sham operated and treated with vehicle (corn-oil, 10 mL/kg).
Groups 2, 3, 4, and 5 were rendered unilaterally cryptorchid and treated with vehicle (10 mL/kg), vitamin E solution (75 mg/kg), vitamin C solution (1.25 g/kg), and combination of vitamin E (75 mg/kg) and vitamin C (1.25 g/kg) solutions, respectively.
Germ cell count, superoxide dismutase (SOD), total protein (TP), and testicular weight (TW) were lower, but malondialdhyde (MDA) was higher in the cryptorchid rats than the sham-operated rats.
When administered separately, vitamins C and E increased germ cell count, SOD, TP, and TW but did not reduce MDA in the cryptorchid rats when compared to the vehicle-treated cryptorchid rats.
However, there was no significant difference in these parameters between vehicle-treated and combined vitamins C- and E-treated rats.
This suggests that vitamins E and C alleviate the germ cell loss and oxidative stress in cryptorchidism when administered separately but not when combined in rats.
American Psychological Association (APA)
Afolabi, Ayobami Oladele& Olotu, Olaolu Opeyemi& Alagbonsi, Isiaka Abdullateef. 2012. Vitamins E and C Alleviate the Germ Cell Loss and Oxidative Stress in Cryptorchidism When Administered Separately but Not When Combined in Rats. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502725
Modern Language Association (MLA)
Afolabi, Ayobami Oladele…[et al.]. Vitamins E and C Alleviate the Germ Cell Loss and Oxidative Stress in Cryptorchidism When Administered Separately but Not When Combined in Rats. ISRN Pharmacology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-502725
American Medical Association (AMA)
Afolabi, Ayobami Oladele& Olotu, Olaolu Opeyemi& Alagbonsi, Isiaka Abdullateef. Vitamins E and C Alleviate the Germ Cell Loss and Oxidative Stress in Cryptorchidism When Administered Separately but Not When Combined in Rats. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502725