![](/images/graphics-bg.png)
HIV Assembly and Budding : Ca2+ Signaling and Non-ESCRT Proteins Set the Stage
Joint Authors
Carter, Carol A.
Ehrlich, Lorna S.
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
More than a decade has elapsed since the link between the endosomal sorting complex required for transport (ESCRT) machinery and HIV-1 protein trafficking and budding was first identified.
L domains in HIV-1 Gag mediate recruitment of ESCRT which function in bud abscission releasing the viral particle from the host cell.
Beyond virus budding, the ESCRT machinery is also involved in the endocytic pathway, cytokinesis, and autophagy.
In the past few years, the number of non-ESCRT host proteins shown to be required in the assembly process has also grown.
In this paper, we highlight the role of recently identified cellular factors that link ESCRT machinery to calcium signaling machinery and we suggest that this liaison contributes to setting the stage for productive ESCRT recruitment and mediation of abscission.
Parallel paradigms for non-ESCRT roles in virus budding and cytokinesis will be discussed.
American Psychological Association (APA)
Ehrlich, Lorna S.& Carter, Carol A.. 2012. HIV Assembly and Budding : Ca2+ Signaling and Non-ESCRT Proteins Set the Stage. Molecular Biology International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-503333
Modern Language Association (MLA)
Ehrlich, Lorna S.& Carter, Carol A.. HIV Assembly and Budding : Ca2+ Signaling and Non-ESCRT Proteins Set the Stage. Molecular Biology International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-503333
American Medical Association (AMA)
Ehrlich, Lorna S.& Carter, Carol A.. HIV Assembly and Budding : Ca2+ Signaling and Non-ESCRT Proteins Set the Stage. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-503333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503333