The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications
Joint Authors
Source
Advances in Materials Science and Engineering
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Engineering Sciences and Information Technology
Abstract EN
An auxetic polyurethane (PU) scaffold was prepared to investigate chondrocyte proliferation under compressive stimulation for cartilage regeneration.
To give a negative Poisson’s ratio to the PU scaffold, volumetric compression with a 3 : 1 ratio was applied during heat treatment.
For the control PU scaffold, the Poisson’s ratio was 0.9 ± 0.25 with elongation at 20% of the strain range.
Poisson’s ratio for experimental specimens was approximately −0.4 ± 0.12 under the same conditions.
In cell proliferation tests, cells were cultivated within the prepared scaffold under compression with a 20% strain range.
With a 20% strain range elongation, the compressive load was approximately 0.3 N.
The experimental group showed a 1.3 times higher cellular proliferation rate than that of the control group after 3 days in culture.
At day 5 of culture, however, the rate of proliferation of the control group increased so that there was no significant difference between groups.
However, collagen content (produced by the cells) in the cell-proliferated medium was 1.5 times higher in the experimental group after 5 days in culture.
This may have been due to the effectiveness of the auxetic structure of the scaffold.
An isotropic compressive load was transmitted to the cells due to the negative Poisson ratio of the scaffold.
American Psychological Association (APA)
Park, Yeong Jun& Kim, Jeong Koo. 2013. The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications. Advances in Materials Science and Engineering،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-503498
Modern Language Association (MLA)
Park, Yeong Jun& Kim, Jeong Koo. The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications. Advances in Materials Science and Engineering No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-503498
American Medical Association (AMA)
Park, Yeong Jun& Kim, Jeong Koo. The Effect of Negative Poisson’s Ratio Polyurethane Scaffolds for Articular Cartilage Tissue Engineering Applications. Advances in Materials Science and Engineering. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-503498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503498