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Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism
Joint Authors
Loro, Vania Lucia
de Menezes, Charlene C.
Santi, Adriana
Medeiros Frescura Duarte, Marta Maria
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The aim of the present study was to evaluate the oxidative stress biomarkers in patients with subclinical hypothyroidism (n=20) and health controls (n=20).
Subjects and Methods.
Total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), thiobarbituric acid reactive substances (TBARSs), catalase (CAT), superoxide dismutase (SOD), and arylesterase (ARE) were analyzed.
Results.
TC, LDL-C, TBARS, and CAT were higher in subclinical hypothyroidism patients, whereas SOD did not change.
Arylesterase activity was significantly lower in the SH group, compared with the control group.
Correlation analyses revealed the association of lipids (TC and LDL-C) with both oxidative stress biomarkers and thyrotropin (TSH).
Thyroid hormones were correlated only with triglyceride levels.
In addition, TSH was significantly correlated with TBARS, CAT, and SOD.
However, no significant correlations were observed after controlling TC levels.
Conclusions.
We found that SH patients are under increased oxidative stress manifested by reduced ARE activity and elevated lipoperoxidation and CAT activity.
Secondary hypercholesterolemia to thyroid dysfunction and not hypothyroidism per se appears to be associated with oxidative stress in subclinical hypothyroidism.
American Psychological Association (APA)
Santi, Adriana& Medeiros Frescura Duarte, Marta Maria& de Menezes, Charlene C.& Loro, Vania Lucia. 2012. Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-503727
Modern Language Association (MLA)
Santi, Adriana…[et al.]. Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism. International Journal of Endocrinology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-503727
American Medical Association (AMA)
Santi, Adriana& Medeiros Frescura Duarte, Marta Maria& de Menezes, Charlene C.& Loro, Vania Lucia. Association of Lipids with Oxidative Stress Biomarkers in Subclinical Hypothyroidism. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-503727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-503727