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Morphometric Analysis of Connective Tissue Sheaths of Sural Nerve in Diabetic and Nondiabetic Patients
Joint Authors
Kundalić, Jasen
Ugrenović, Sladjana Z.
Antić, Vladimir
Jovanović, Ivan
Petrović, Vladimir
Stefanović, Natalija
Živković, Vladimir S.
Stojanović, Vesna R.
Kundalić, Braca
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
One of the most common complications of diabetes mellitus is diabetic neuropathy.
It may be provoked by metabolic and/or vascular factors, and depending on duration of disease, various layers of nerve may be affected.
Our aim was to investigate influence of diabetes on the epineurial, perineurial, and endoneurial connective tissue sheaths.
The study included 15 samples of sural nerve divided into three groups: diabetic group, peripheral vascular disease group, and control group.
After morphological analysis, morphometric parameters were determined for each case using ImageJ software.
Compared to the control group, the diabetic cases had significantly higher perineurial index (P<0.05) and endoneurial connective tissue percentage (P<0.01).
The diabetic group showed significantly higher epineurial area (P<0.01), as well as percentage of endoneurial connective tissue (P<0.01), in relation to the peripheral vascular disease group.
It is obvious that hyperglycemia and ischemia present in diabetes lead to substantial changes in connective tissue sheaths of nerve, particularly in peri- and endoneurium.
Perineurial thickening and significant endoneurial fibrosis may impair the balance of endoneurial homeostasis and regenerative ability of the nerve fibers.
Future investigations should focus on studying the components of extracellular matrix of connective tissue sheaths in diabetic nerves.
American Psychological Association (APA)
Kundalić, Braca& Ugrenović, Sladjana Z.& Jovanović, Ivan& Stefanović, Natalija& Petrović, Vladimir& Kundalić, Jasen…[et al.]. 2014. Morphometric Analysis of Connective Tissue Sheaths of Sural Nerve in Diabetic and Nondiabetic Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-504966
Modern Language Association (MLA)
Kundalić, Braca…[et al.]. Morphometric Analysis of Connective Tissue Sheaths of Sural Nerve in Diabetic and Nondiabetic Patients. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-504966
American Medical Association (AMA)
Kundalić, Braca& Ugrenović, Sladjana Z.& Jovanović, Ivan& Stefanović, Natalija& Petrović, Vladimir& Kundalić, Jasen…[et al.]. Morphometric Analysis of Connective Tissue Sheaths of Sural Nerve in Diabetic and Nondiabetic Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-504966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-504966