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Acute Myeloid Leukemia Evolving from JAK 2-Positive Primary Myelofibrosis and Concomitant CD5-Negative Mantle Cell Lymphoma : A Case Report and Review of the Literature
Joint Authors
Khedr, Salwa
Mangray, Shamlal
Treaba, Diana O.
Winer, Eric S.
Castillo, Jorge J.
Jackson, Cynthia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Primary myelofibrosis (formerly known as chronic idiopathic myelofibrosis), has the lowest incidence amongst the chronic myeloproliferative neoplasms and is characterized by a rather short median survival and a risk of progression to acute myeloid leukemia (AML) noted in a small subset of the cases, usually as a terminal event.
As observed with other chronic myeloproliferative neoplasms, the bone marrow biopsy may harbor small lymphoid aggregates, often assumed reactive in nature.
In our paper, we present a 70-year-old Caucasian male who was diagnosed with primary myelofibrosis, and after 8 years of followup and therapy developed an AML.
The small lymphoid aggregates noted in his bone marrow were neoplastic in nature and represented bone marrow involvement by a CD5-negative mantle cell lymphoma (MCL) that presented without any associated lymphadenopathy.
We reviewed the English medical literature to identify a single case report of simultaneous association of AML and a MCL in the bone marrow.
The unusual association presented here suggests an increase in observer awareness to apparently benign lymphoid aggregates in chronic myeloproliferative neoplasms.
American Psychological Association (APA)
Treaba, Diana O.& Khedr, Salwa& Mangray, Shamlal& Jackson, Cynthia& Castillo, Jorge J.& Winer, Eric S.. 2012. Acute Myeloid Leukemia Evolving from JAK 2-Positive Primary Myelofibrosis and Concomitant CD5-Negative Mantle Cell Lymphoma : A Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505348
Modern Language Association (MLA)
Treaba, Diana O.…[et al.]. Acute Myeloid Leukemia Evolving from JAK 2-Positive Primary Myelofibrosis and Concomitant CD5-Negative Mantle Cell Lymphoma : A Case Report and Review of the Literature. Case Reports in Hematology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-505348
American Medical Association (AMA)
Treaba, Diana O.& Khedr, Salwa& Mangray, Shamlal& Jackson, Cynthia& Castillo, Jorge J.& Winer, Eric S.. Acute Myeloid Leukemia Evolving from JAK 2-Positive Primary Myelofibrosis and Concomitant CD5-Negative Mantle Cell Lymphoma : A Case Report and Review of the Literature. Case Reports in Hematology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505348