Grape Seed Procyanidin Extract Improves Insulin Production but Enhances Bax Protein Expression in Cafeteria-Treated Male Rats
Joint Authors
Pinent, Montserrat
Cedó, Lídia
Blay, Mayte
Ardévol, Anna
Castell-Auví, Anna
Pallarès, Victor
Source
International Journal of Food Science
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Engineering Sciences and Information Technology
Abstract EN
In a previous study, the administration of a grape seed procyanidin extract (GSPE) in female Wistar rats improved insulin resistance, reduced insulin production, and modulated apoptosis biomarkers in the pancreas.
Considering that pharmacokinetic and pharmacodynamic parameters in females are different from these parameters in males, the aim of the present study was to evaluate the effects of GSPE on male Wistar cafeteria-induced obese rats.
The results have confirmed that the cafeteria model is a robust model mimicking a prediabetic state, as these rats display insulin resistance, increased insulin synthesis and secretion, and increased apoptosis in the pancreas.
In addition, GSPE treatment (25 mg/kg of GSPE for 21 days) in male rats improves insulin resistance and counteracts the cafeteria-induced effects on insulin synthesis.
However, the administration of the extract enhances the cafeteria-induced increase in Bax protein levels, suggesting increased apoptosis.
This result contradicts previous results from cafeteria-fed female rats, in which GSPE seemed to counteract the increased apoptosis induced by the cafeteria diet.
American Psychological Association (APA)
Cedó, Lídia& Castell-Auví, Anna& Pallarès, Victor& Blay, Mayte& Ardévol, Anna& Pinent, Montserrat. 2013. Grape Seed Procyanidin Extract Improves Insulin Production but Enhances Bax Protein Expression in Cafeteria-Treated Male Rats. International Journal of Food Science،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-505376
Modern Language Association (MLA)
Cedó, Lídia…[et al.]. Grape Seed Procyanidin Extract Improves Insulin Production but Enhances Bax Protein Expression in Cafeteria-Treated Male Rats. International Journal of Food Science No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-505376
American Medical Association (AMA)
Cedó, Lídia& Castell-Auví, Anna& Pallarès, Victor& Blay, Mayte& Ardévol, Anna& Pinent, Montserrat. Grape Seed Procyanidin Extract Improves Insulin Production but Enhances Bax Protein Expression in Cafeteria-Treated Male Rats. International Journal of Food Science. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-505376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505376