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Ways of Coping and Biomarkers of an Increased Atherothrombotic Cardiovascular Disease Risk in Elderly Individuals
Joint Authors
von Känel, Roland
Mills, Paul J.
Ziegler, Michael G.
Patterson, Thomas L.
Allison, Matthew
Dimsdale, Joel E.
Ancoli-Israel, Sonia
Grant, Igor
Roepke, Susan K.
Mausbach, Brent T.
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To investigate the relationship between coping and atherothrombotic biomarkers of an increased cardiovascular disease (CVD) risk in the elderly.
Methods.
We studied 136 elderly caregiving and noncaregiving men and women who completed the Ways of Coping Checklist to assess problem-focused coping, seeking social support (SSS), blamed self, wishful thinking, and avoidance coping.
They had circulating levels of 12 biomarkers measured.
We also probed for potential mediator and moderator variables (chronic stress, affect, health behavior, autonomic activity) for the relation between coping and biomarkers.
Results.
After controlling for demographic and CVD risk factors, greater use of SSS was associated with elevated levels of serum amyloid A (P=0.001), C-reactive protein (CRP) (P=0.002), vascular cellular adhesion molecule (VCAM)-1 (P=0.021), and D-dimer (P=0.032).
There were several moderator effects.
For instance, greater use of SSS was associated with elevated VCAM-1 (P<0.001) and CRP (P=0.001) levels in subjects with low levels of perceived social support and positive affect, respectively.
The other coping styles were not significantly associated with any biomarker.
Conclusions.
Greater use of SSS might compromise cardiovascular health through atherothrombotic mechanisms, including elevated inflammation (i.e., serum amyloid A, CRP, VCAM-1) and coagulation (i.e., D-dimer) activity.
Moderating variables need to be considered in this relationship.
American Psychological Association (APA)
von Känel, Roland& Mausbach, Brent T.& Dimsdale, Joel E.& Mills, Paul J.& Patterson, Thomas L.& Ancoli-Israel, Sonia…[et al.]. 2012. Ways of Coping and Biomarkers of an Increased Atherothrombotic Cardiovascular Disease Risk in Elderly Individuals. Cardiovascular Psychiatry and Neurology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-505426
Modern Language Association (MLA)
von Känel, Roland…[et al.]. Ways of Coping and Biomarkers of an Increased Atherothrombotic Cardiovascular Disease Risk in Elderly Individuals. Cardiovascular Psychiatry and Neurology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-505426
American Medical Association (AMA)
von Känel, Roland& Mausbach, Brent T.& Dimsdale, Joel E.& Mills, Paul J.& Patterson, Thomas L.& Ancoli-Israel, Sonia…[et al.]. Ways of Coping and Biomarkers of an Increased Atherothrombotic Cardiovascular Disease Risk in Elderly Individuals. Cardiovascular Psychiatry and Neurology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-505426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505426