Vascular Response to Graded Angiotensin II Infusion in Offspring Subjected to High-Salt Drinking Water during Pregnancy : The Effect of Blood Pressure, Heart Rate, Urine Output, Endothelial Permeability, and Gender
Joint Authors
Pezeshki, Zahra
Eshraghi-Jazi, Fatemeh
Nematbakhsh, Mehdi
Source
International Journal of Vascular Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Rennin-angiotensin system and salt diet play important roles in blood pressure control.
We hypothesized that the high-salt intake during pregnancy influences the degree of angiotensin-dependent control of the blood pressure in adult offspring.
Methods.
Female Wistar rats in two groups (A and B) were subjected to drink tap and salt water, respectively, during pregnancy.
The offspring were divided into four groups as male and female offspring from group A (groups 1 and 2) and from group B (groups 3 and 4).
In anesthetized matured offspring mean arterial pressure (MAP), heart rate and urine output were measured in response to angiotensin II (AngII) (0-1000 ng/kg/min, iv) infusion.
Results.
An increase in MAP was detected in mothers with salt drinking water (P<0.05).
The body weight increased and kidney weight decreased significantly in male offspring from group 3 in comparison to group 1 (P<0.05).
MAP and urine volume in response to AngII infusion increased in group 3 (P<0.05).
These findings were not observed in female rats.
Conclusion.
Salt overloading during pregnancy had long-term effects on kidney weight and increased sex-dependent response to AngII infusion in offspring (adult) that may reveal the important role of diet during pregnancy in AngII receptors.
American Psychological Association (APA)
Pezeshki, Zahra& Eshraghi-Jazi, Fatemeh& Nematbakhsh, Mehdi. 2014. Vascular Response to Graded Angiotensin II Infusion in Offspring Subjected to High-Salt Drinking Water during Pregnancy : The Effect of Blood Pressure, Heart Rate, Urine Output, Endothelial Permeability, and Gender. International Journal of Vascular Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-505505
Modern Language Association (MLA)
Pezeshki, Zahra…[et al.]. Vascular Response to Graded Angiotensin II Infusion in Offspring Subjected to High-Salt Drinking Water during Pregnancy : The Effect of Blood Pressure, Heart Rate, Urine Output, Endothelial Permeability, and Gender. International Journal of Vascular Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-505505
American Medical Association (AMA)
Pezeshki, Zahra& Eshraghi-Jazi, Fatemeh& Nematbakhsh, Mehdi. Vascular Response to Graded Angiotensin II Infusion in Offspring Subjected to High-Salt Drinking Water during Pregnancy : The Effect of Blood Pressure, Heart Rate, Urine Output, Endothelial Permeability, and Gender. International Journal of Vascular Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-505505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505505